How to Beat Plague Inc. Prion on Normal

Updated on March 6, 2016

Beating Prion on Normal

This tutorial, while similar to the Virus tutorial I posted, is a little different in the way you go about the game. Please make sure you read the steps carefully and follow them to a T. If you have come this far, you probably know the game pretty well now. Let's get this started!

First things first: you are allowing symptoms to mutate.

  1. Start your virus in South Africa.
  2. Build DNA points to 50.
  3. Get Air Resistance 1.
  4. Get Air Resistance 2.
  5. Get Water Resistance 1.
  6. Get Blood 1.
  7. Build DNA Points to 50.
  8. Get Water Resistance 2.
  9. Get Drug Resistance 1.
  10. Get Heat Resistance 1.
  11. Get Cold Resistance 1.
  12. Build DNA Points to 100.
  13. Get Drug Resistance 2.
  14. Get Heat Resistance 2.
  15. Get Cold Resistance 2.
  16. Get Genetic Hardening 1.
  17. Build your points to 100 or until everyone is infected.
  18. Once you have either reached 100 points or everyone is infected, put points into symptoms leading to Total Organ Failure. Spend your remaining points into anything else that is lethal. Don't worry about the cure. However, if you want you can spend any additional points to slow the cure for a higher score.

Update to Tutorial

I have noticed there being a change in the current tutorial as it stands.

All you have to do is put your additional points into genetic reshuffle 1 and genetic reshuffle 2 to prevent the cure from going 100%

Video: Prion on Normal Walkthrough

Updated: My stats as of 3/27/2014.
Updated: My stats as of 3/27/2014.

About the Author

Ashleign is my alias and a character I play on the internet. I have used this nickname for several years. I have worked in IT for about four years. Before that, I worked as an EMT in EMS. There, I drove the ambulance mostly, but I can say that I was in the room while a life was actually being saved—that was a cool thing to see. Bless our troops, fire, police, and EMS workers they have an incredibly hard job, and I love them with every bit of my heart. Especially the police.

I've been working very hard on these tutorials for you and appreciate any and all feedback you want to provide. Please let me know how you did, I would love to hear from you!

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    • profile image

      N/A 19 hours ago

      The cure got to 98%. Just barely won.

    • profile image

      Mackenzy 2 weeks ago

      For people saying it didn't work and that you followed it to a T obviously you didn't. She has worked hard on these tutorials and doesn't deserve the bullshit i see in the comments. If you followed her steps to the letter, then it should work. I have used her tutorials for the past hour and have gotten all the way up to this disease with her help and i kept dying for days stuck at the Bacteria level. So obviously you didn't follow instructions therefore it isnt her fault

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      Fabian 6 weeks ago

      Doesn’t work I’ve done it 6 times and I always get eradicated before they all die.

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      Ganegirl 7 weeks ago

      Doesnt work for me.. i tried it two times still canmt beat it

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      William 2 months ago

      for those who lose, I beat it at 99% left to cure it, after you use Genetic reshuffles, make sure to devolve transmissions and abilities and put towards symptoms like Coma and Insanity (To the left) that slows down progress, then just pray that the leading nation of the cure dies out. Hope this helps

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      Michael 2 months ago

      You tutorials work like like.... idk but they’d work

      All of them thank you!

    • profile image

      Marcus 2 months ago

      this worked thank you

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      Joe 3 months ago

      I followed to a T and was defeated twice at the last minute. The most DNA points I can get after step 16 is 71 and then it outright stops. Devolved all symptoms and abilities to fight the cure, which takes less than a minute to reach 100%. Ive lost to this level a total of 9 times now. :(

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      Geoff 3 months ago

      On the normal prion I found that I had to devolve symptoms to escape detection. I reached 98% world infection before new disease was receiving attention. Once I got 100% your advice of ramping up symptoms to kill and genetic reshuffling worked like a charm.

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      Gravy 4 months ago

      Barely worked, however did in the end! I had to take some extra action to defend against the cure though, like devolving certain transmissions and abilities, and evolving the Prion's special ability at the beginning, along with adding extra lethal symptoms, but it worked!

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      Justice Marie 4 months ago

      I love your tutorials!! They have all worked for me. I hope you make more for the other stuff in the game.

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      SarahMariePardy 4 months ago

      This doesn't work. I tried it about 5 times before going to a new walkthrough that told me to devolve symptoms as they come and focus on transmission + cold res, where as yours says to allow symptoms. Once everyone was infected the cure hadn't even started. So then I evolved symptoms to total organ failure and as more points came in (plus I devolved transmissions for more points since everyone was ill already) I used them to fight the cure. Once the symptoms start, the cure starts and it's very fast. I was BARELY able to complete it this way, but did. 93% cure when I finished.

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      Vicki 4 months ago

      Even with your update this still doesn't work. I eradicated 97% of the world but the cure saved the last 3%. Would love to know if anyone has completed this one or if they've broken it with the recent tweaks? I just want to move on...

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      Matt 5 months ago

      Yep this one does NOT work

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      Wow 5 months ago

      First guide that I've looked at that actually hasn't worked at all.

      Following it to the letter results in less than a quarter of the total population dead and 100% cured.

      Not allowing symptoms to mutate results in half the amount of people dead but still 100% cured.

      Doesn't really work if you follow this guide at all.

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      Jake 6 months ago

      I had everyone infected and once I activated total organ failure the cure caught up really fast and people weren't dying fast at all

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      Louis 6 months ago

      No Help... Still lost

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      Rich 6 months ago

      This was THE most useless guide I've ever tried. No help, I was doing better on my own.

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      Redcloud 6 months ago

      This doesn't work at all by the time everyone is infected I barely enough dna points for total organ failure and sometimes not enough so no gen resuffle 1,2 which allows the cure to reach 100%

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      Shelby 7 months ago

      By the end, you have no DNA points to spend. Production slows down. You can't buy Organ Faliure, let alone Genetic Reshuffle...

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      Doogo moog 7 months ago

      you said air resistance

    • profile image

      Wow 8 months ago

      Finished with 98% cure

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      DragonSkitters 8 months ago

      Air Resistance?

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      Fox Gaming 8 months ago

      @Stuqid Water Resistance is for Boats becoming immune to your virus (As the game describes it, getting new air filters) and Air Resistance is the same, but for Airplanes. The Resistances are for two things (That I've noticed.) 1. Allowing Boats and Airplanes to become infected again after getting new air filters, and 2. Increasing chance of Airplanes and Boats to become infected.

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      orteam 8 months ago

      Thanks :)

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      deatheye 9 months ago

      advice use the first dna gene u get and when everyone is infected and dying and the cure is close to be done devolve the weak stuff

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      Revampedharpy09 9 months ago

      just going to give some advice here guys, i tried this as written, and even with genetic reshuffle 1, 2 and 3 it didnt work, so i tried again, this time ignoring the "allow symptoms to mutate" and devolved them just like with bacteria and it has worked. aside from that change, i used the tutorial as written.

      That said, ive only tried it once, so whether or not this is a reliable method, i cant say.

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      Stuqid 11 months ago

      What is Water and Air Resistance?

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      Clark Kim 12 months ago

      Just finished. 1st thing is 1st. You need to follow the stratagy exactly till step 16. (Except, one, you might want to try livestock, instead of blood. Two, step 14 wouldn't be necessary for you to spread infection further in hot climate regions. Three, do not allow any symptoms during the infection.)

      Now, here are several essential points.

      1. Confirm the every single one in the world is infected.

      2. Start retrieving DNA points from Abilities (Heat/Cold resistance) and Transmission (Air/Water/Livestock)

      3. Begin developing symptoms till total organ failure first!

      (Also, at this point, you can now allow the symptoms to be developed)

      4. Concentrate on investing DNA points in Abilities (Drug resistance/Genetic Hardening/Genetic Reshuffle, these 3 factors have to be maxed out!)

      5. If possible, coma also would be greatly helpful to prevent reaching cure 100%.

      At the end, the result were the cure development 83% and wipe out in 1506 days.

      Wish you luck!!

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      Cara 12 months ago

      I have tried this about 10 times and it always gets cured before everybody dies off. I got really close but the cure beat me. What DNA can we use? Which ones would be the best to make sure I am able to beat this level?

    • profile image

      someone 12 months ago

      this one did not help me the other ones helped but not this one i followed everything and i did not work plz

    • Fox Gaming profile image

      Fox Gaming 12 months ago

      Great Guide, but what if it evolves a deadly symptom while i'm still trying to infect?

    • profile image

      Anonymous 13 months ago

      I followed this walkthrough EXACTLY as written. I've used several other of these and they worked very well. This one just completely allowed the cure to be completed and didn't stop it. I lost with only half a billion people dead and the cure just stopped the disease in its tracks and easily caused me to lose. Please add something for cure prevention!!!!

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      Wow! 13 months ago

      Wait a minute! I used this tutorial on parasite and it worked fine! Guess I've got Prion sorted out now!

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      Wow! 13 months ago

      I finished in 597 days and the cure was only at 43%

      It is common sense after total organ failure. Just keep saving up for genetic reshuffles. And evolve deadly symptoms (increase the amount of daily deaths).

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      Annonymous 13 months ago

      When the humans started to "cure" my disease (Raggmunk) I got the Neural atrophy 1 and 2 plus Genetic hardening 2 just to slow the cure down which (probably) saved me. ended up winning with the cure at 73% (in addition to these abillities, I used 2 reshuffles) Hopefully you can test this and find it useful (at least to some extent)

    • Jen Anderson profile image

      Jen Anderson 13 months ago

      I followed this a few times but had no success, so I followed the same plan I did for bacteria and just managed to squeak by with completion at 1381 days and the cure at 94%. I devolved all mutations until there were no healthy people left and then dumped points into symptoms to get to TOF. Then I used any remaining points on genetic reshuffles and hardening. Thanks for the pointers though

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      Didnt work 13 months ago

      Didn't work!!!!!

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      Sam 15 months ago

      It never worked for me even i followed the rules☹️

    • Ashleign profile image

      Ashleign 16 months ago

      Well, I try to approve the comments of people trying to help with alternative solutions. I am glad that DMisteri was able to help you. Special thanks for DMisteri!

    • profile image

      Eljay77 16 months ago

      Didn't work for me solely using Ashleighns (First time Ash's stuff hasn't worked) but with a bit of help from DMisteri post I FINALLY got there! Simply need a bit of patience and a little more hard work.

      Thanks guys

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      Berke 16 months ago

      Needed last minute medical upgrades

    • Ashleign profile image

      Ashleign 16 months ago

      They aren't following the directions and blame me for them skipping ahead.. It happens. I know the tutorials work.

    • profile image

      Yo 16 months ago

      I don't know how this doesn't work for some. I followed all your steps for everyone and ow I beat the game lol so either way your tips are amazing and thank you

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      Berta 16 months ago

      Feel bad for cheating a tad... but i cant help it without u an ur amasing tips id still b stuck on bacteria getting my ass kicked by the cure!! Lots of love xxx

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      ed 17 months ago

      I beat the game at 78% cure. I only evolved up to : Air 2, Water 2, Heat Resistance 2, and Cold Resistance 2. Then I evolved ONLY cough and sneezing just to infect everyone. The disease was noticed but the cure progress slowly.

      I waited and collected DNA points up to 150 then I evolved symptoms up to TOF, Coma, and Paralysis.

      Then you must evolve up to Neural Atrophy 3. Trust me, this slows down the cure progress as it affects the brain of the researchers.

      Lastly I work my way up to evolving Genetic Reshuffle 2.

      Game is finished and a success.

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      Shinobigarth 17 months ago

      works, but you HAVE to devolve all transmission stuff (including the abilities that deal with infectivity) once everyone is sick, and stay on top of the cure at the end, getting Genetic Reshuffles as soon as you can. basically at the end put everything into Reshuffles, TOF, Coma, Paralysis and i did Seizures also. devolve everything else including the symptoms used to get to TOF, Coma, etc to give you more points for the Reshuffles.

      worth noting i also had the one gene mod that gives you 4 points for a devolve, and i just barely made it, so i almost feel like that mod is pretty necessary.

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      Janie 17 months ago

      i've followed this five times now and it doesn't work

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      Janie 17 months ago

      never worked, the cure got to 100%

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      mucholoco 17 months ago

      Hi! Did you mean Air Transmission for (3-4) and Water Transmission for (5,8)?

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      LeeLee 18 months ago

      once all was infected, I devolved all transmissions, heat, cold, and rash. Evolved genetic shuffle and this triggered enough points to keep coming in so I increased legality/harder to cure symptoms and it work with 96% to cure

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      Jo 18 months ago

      This also works for parasite. Whoops.

    • Ashleign profile image

      Ashleign 18 months ago

      Oddly enough I am working on a Brutal Santa's little helper..

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      aftrprzn 18 months ago

      I've beaten all the regular scenarios on easy, normal, and brutal; I can't beat any of them on mega-brutal.

      Also, I can't beat "Santa's Little Helper" on brutal.

      Would love some help on these, please.

      Thanks in advance.

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      firox 18 months ago

      put tutorials about senerios

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      JonDon 19 months ago

      @chuck - as someone who has followed every detail to a T and still failed, I feel compelled to say that in a game like Plague which is so full of and so dependent upon variables and endless permutations, it doesn't really matter what strategy you follow or how closely you adhere to it - there will always be the possibility of undesirable outcomes. Just like in real life. This is certainly not a knock on the author's strategies. I am very grateful for his input and help as well as those here who also have offered their variations and walkthrus in the comments.

      Thanks to everyone.

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      harms 19 months ago

      at the end it completely stopped giving me DNA points so I couldn't fight the cure

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      chuck 19 months ago

      Ive used all your tutorials thusfar and i have to say they work A+ 100%. Users complaining of defeat must not be following the tutorial to a T like you suggest...... Thanks for your hard work!

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      DMisteri 19 months ago

      First and foremost Devolve all Symptoms

      Follow the first 11 steps in the tutorial except when you get to step 6 use Livestock 1 not blood 1 since the biggest disaster that came from Prion was Mad Cow Disease.

      Use Cold Resistance 2 to completely infect the world and in the process while you wait build up your points you will need them.

      Once the world is totally infected start adding Symptoms starting with Insomnia and working your way up the middle to Organ Failure. Add remaining points to Bird 1.

      The Cure will rise however as your points build add them to Genetic Reshuffle 1,2,and 3 by this time the Cure will stop and the world will be 90% dead. I hope this help and have fun wiping out the world you sick individuals

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      Tony Stank 19 months ago

      I DID IT


      I used the guide, and that didnt work AT ALL

      So, I did it this way

      Drug Resist 1 and 2, Genetic Hardening 1 and 2

      Devolved all mutations as they came

      Air 1 and 2, Water 1 and 2, Extreme Bioaresol

      Birds 1 and 2, rats 1

      Cold 1 and 2, heat 1

      Neural Atrophy 1 and 2

      As soon as everyone was infected, and I was at about 107 DNA points, I went in and put in Coughing, Sneezing, Immune Suppression, and Total Organ Failure.

      I devolved all my transmissions and the heat and cold.

      I ramped up my Genetic Reshuffle 1-3

      Cure is still 79%

      And the world is dyiiiiinnnngggggg!


    • profile image

      noirp 20 months ago

      it work! while there's so many cures i was like don't care about the cures

    • Ashleign profile image

      Ashleign 20 months ago

      The video and the tutorial are accurate. Don't get ahead of the tutorial it's designed to take long.

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      theanubisdragon 21 months ago

      did every thing in video defeat in under 2 mins wtf

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      Wesbest 21 months ago

      I had everyone infected with no symptoms,and then built up to total organ failure,but the cure was made crazy fast. How do I slow to cure.?

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      Andrei 21 months ago

      I killed all the people finishing with 0 DNA points and 99% of cure. :)

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      Jessica 22 months ago

      Followed this exactly. I found that the cure was quickening which seemed to be a common issue and I didn't have enough for Genetic Reshuffle 2 so then I devolved my Heat, Cold, Blood, Air, Water and received 2 DNA points for each that helped me with the Reshuffle. The DNA points automatically rose and within seconds I had enough points to keep assigning symptoms and then eventually the cure stopped at 83%.

      THANK YOU :D

      I was stuck on this one for a longgggggg time.

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      nikolas 22 months ago

      it did not work, i followed the tutorial step by step, there is 500k people left in the world and they invent the cure at an astonishing rate

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      Lizzy 23 months ago

      This didn't work for me. I read the comments before starting my first playthrough of prion, and seeing as how so many people found that this tutorial didn't work out for them, I opted to devolve any symptom mutations until all of my countries were infected, so that I would have a head start once it got noticed. Aside from that, I followed the tutorial "to the T" and even though everyone was infected by the time I evolved total organ failure, the cure still beat me before I managed to kill off more than almost 1/3 of the world population.

      I love your tutorials and this is the only one that hasn't worked for me thus far. Perhaps you should revamp it entirely seeing as how so many people found that it did not work for them? Regardless thank you for your helpful posts!

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      Tanner 23 months ago

      this worked on normal, but not brutal

    • Ashleign profile image

      Ashleign 23 months ago

      I'll re-work it and see what I come up with thanks for the feedback

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      PlagueRat 23 months ago

      Followed this tutorial to the "T" 5 times in a row, each time the result was the same.. Cure happens before 50% eradication of population.

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      Plague inc. Evolved 2 years ago

      It works

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      Undyne 2 years ago

      Work! i get DNA points Faster!

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      Rozack 2 years ago

      1.Start in Saudi Arabia

      2.Don't let Lethality Way Up!

      3.follow Asgleign

      4.have fun!

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      Lol 2 years ago

      Worked like a charm, thanks!

    • Ashleign profile image

      Ashleign 2 years ago

      Wow, haven't had this kind of comment for a while. I remember following up on this tutorial just the other day and it worked perfectly. Did you follow the tutorial exactly?

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      Maddy 2 years ago

      100% cure before even Canada got completely infected! Didn't work

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      Dararith 2 years ago

      Following this exactly literally only allowed me to kill about 500 million people, maximum. Otherwise, cure would be able to surface before then.

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      Staci 2 years ago

      Dude i ended up eradicating myself because greenland didn't infect faster than they died.... I'm pissed...

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      A=Unknown 2 years ago

      Treat the disease as a Bacteria not as a virus. It will help. Or Simply don't let the symptons mutate.No need to go to Heat Resistance 2, keep it at 1,but get the cold resistance at 2. Use Rodents instead of Blood.

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      42ndsheep 2 years ago

      i had to change this to make it work, but good baseline i guess (I won with 96% cure and no more genetic reshuffles, immensely close game, the cure had actually gotten to 99% when i was able to reshuffle lol)

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      Pinkie Pie 2 years ago

      Add loved it.

      Won on my 1st try.

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      Terry 2 years ago

      I had almost all symptoms and the cure hadn't even started but it still caught up in the end. This is a bad tutorial.

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      Karl 2 years ago

      Start in egypt- 2 port 1 airport

      Get heat resistance 1, then drug reaistance 1 (egypt will spread to saudi,, US, and Spain/UK) then get cold resistance. At the same time get water and air transmission only. Dont use any others since its detectable. Devolved any symptom mutated. Do not let any sympton exist until all people are infected. Depending on ur game, change the peiority slightly whether to increase the defend(ability) or straight kill (symptoms) but make sure if u ever choose to expose ur desease, make sure u have enough point to go straight to organ failure. Thats how i played. Took me 2020 but it was easy.

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      Green 2 years ago

      It took me 2 times to beat it

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      UncleKid 2 years ago

      I hope you guys figure it out for yourself. This guide is misguiding. You cant really win with this. I follow it partiolly and add some minor modifications.

      1. Start in India

      2. Dont take Heat res 2 (its useless)

      3. Take Roden instead to speed up EU and US spread

      4. For more fatality I add Internal Haemorrhaging

      5. Use all your spare points to slow cure

      I manage to win it this way. Cure get to 91 but able to slow it down.

      Hope this will help.

      Good luck exterminating humanity :)

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      You 2 years ago

      I was followed this to the teeth. But every time it goes to slow. I got every single symptom at once before the cure even started and it still caught up and one

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      Zach 2 years ago

      It didn't work for me. I tried it like 10 times. I follow the instructions exactly, but it does not give me DNA points fast enough.

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      Savis 2 years ago

      Thanks for your guide! I followed exactly and I finally beat it, but had to use a few tweaks. Even following everything exactly the cure progress got up to 93% before I took further action. After your steps I devolved Water/Air 2, Blood 1, and a few of the symptoms not leading to total organ failure. I also had to end up buying all 3 of the Prior special abilities, this knocked the cure rate back to 83% and gave the disease enough time to finish off the planet.

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      Sparky 2 years ago

      I have been trying this way for the past few days, tons of games later, I still keep losing. I even tried hiding the symptoms by not letting them evolve.

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      Death 2 years ago

      I am following the instructions correctly, but I still keep losing, what's up with that?

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      Shadow 2 years ago

      This method works to the letter. However, a sure-fire way of not allowing the cure to reach 100% (or so for me anyway) it is essential you have genetic reshuffle 1, insanity and darwinist so you can get more DNA earlier on.

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      Eric 2 years ago

      Iceland and Greenland survived because I started killing when I reached 100 DNA points, disregard that and wait until everyone is infected like the other diseases.

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      Ernes 2 years ago

      Tried this 12 times no luck

    • Vee Pei Wong profile image

      Vee Pei Wong 2 years ago

      how about for the brutal mode?

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      Ray 2 years ago

      It didn't quite work. Not everyone in Greenland could be infected before the cure could be deployed :/

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      Kimberly 2 years ago

      On my 5th go around I decided that I needed to play the long game. Which, when it was all said and done, took about ten game years just to infect the world. This seemed to work for me and I beat Prion on normal (without any of the extras that you get from purchasing the full version) with a cure of 90%. The secret is patience and keeping as many DNA points built up as a reserve for when you start killing people off. Since you don't get DNA points as quickly with the Prion when people start dying, plus people die so SLOWLY, you need to have a lot in reserve to just go for the death symptoms as early and quickly as possible.

      I started in China and let it spread naturally until I had 100 DNA points built up. I bought Air I, Water I, and Drug Resistance I then let the DNA points build up to 100 again. I then purchased Cold Resistance I, Heat Resistance I, and Drug Resistance II.

      After that, I let the game go. I didn't purchase anything else and let the Prion continue to spread, building up DNA points while I waited. If any symptoms evolved, I immediately devolved them. When there were no healthy people left in the world, I had (I think) 134 DNA points. I then devolved Air and Water I as well as Heat and Cold Resistance I.

      I then used my points to purchase Insomnia, Paranoia, Insanity, Coma, Seizures, and Paralysis. My goal was to get as many fatal symptoms that would also slow the cure rate down. While I was getting these, the cure was shooting up to almost 50% with only about 2 million dead/dying. Using the DNA points that built up due to deaths, I then purchased Coughing then Pneumonia (because it was cheaper than sneezing) and worked my way up to Organ Failure, Systemic Infection, and Genetic Reshuffle I.

      I also made sure to devolve coughing and pneumonia as well as insomnia and paranoia (basically any symptom that didn't slow the cure rate down or lead to death) because every DNA point counts.

    • Vee Pei Wong profile image

      Vee Pei Wong 2 years ago

      any tips for prion brutal?

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      That one guy 2 years ago

      This is the only walk through that didn't work. :( It worked on casual but not normal.

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      Robz 2 years ago

      your tips have been useful, but not on prion. like some people here, the cure went really fast (or the kill went really slow). i have tried improvised on your technique by not using bio-aerosol and try to get 100+ points so i can spend on more killer symptoms and still getting outpaced by the cure.