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"Plague Inc. Evolved": Simian Flu on Normal

Ashleign is a woodworker and yard enthusiast. She can be found as enthusiast.mysticalnerdtv on Instagram and mysticalnerd on Twitch.


Take Your Stinking Paws Off Me, You Damned Dirty Ape!

So it seems like yesterday I crawled out bed and ran downstairs at 10pm at night to see my father watching Planet of the Apes. Of course, back then we had this ancient technology called VHS. Kids today of course have no idea what that is, unless their parents were 80's babies and still have old copies of the Lion King.

No the day of recording over crappy movies to record all your favorite shows is over unfortunately. With the end of VHS and the move into DVD which will soon be replaced by BluRay or whatever else those squirrelheaded tech gurus over in silicon valley come up with next.

Here we have the Simian Flu, a plague that you will want to start in the Country of Indonesia.

This one is a lot different than the others. I am just going to let you know, you may encounter a moderate amount of BS in this tutorial.

Take a Deep Breath

Let's get this thing started here guys. We are venturing into unknown territory. Plague Inc is renowned for its casual gameplay style. Not anymore. Simian Flu is going to take some serious attention and ability to react quickly.

Allow all Symptom mutations except: Neuro-Enhancement 1 and except: Lethal Symptoms

Our Mission:

Infect the entire world. Allow Apes to take over. Kill the entire world. Sounds simple right? Wrong.

Start in Indonesia

Build your DNA Points to (20)


  • Simian Neuro-Genesis
  • Organised Travel

Build your DNA Points to (15)


  • Ape Colonies

Use Your Ape Colony ability on Indonesia

Build your DNA Points to (16)


  • Cognitive Shift
  • Ape Rampage

Build your DNA Points to (30)


  • Fomites 1
  • Fomites 2


  • Cold Resistance 1

Once Indonesia's Ape Colony Bar is full, use Migration to move them to another country. (doesn't matter which)

Create another Colony in another Country (Doesn't matter which just not Indonesia)

Build your DNA Points to (40)


  • Education
  • Drug Resistance 1
  • Transmissions:
  • Inter-Genus Dissemination 1

Create another Colony in another country (Doesn't matter which)

Build your DNA Points to (50)


  • Fomites 3
  • Air 1
  • Water 1
  • Sebaceous Excretion

Build your DNA Points to (60)


  • Primal Awareness
  • War Paint
  • Logistics
  • Horseback Riding

This would be a good time to pause your game and move your colonies around. You want to spread them across the map. (This is for when the research facilities come into play) Spread them out but not too far apart.

Unpause your game.

You should see any moment now, little grey cure blocks they will have a beaker on them.

Build your DNA Points to (80)


  • Hominidae Bridge
  • Air 2
  • Water 2

Now, use your little fist or (Ape Rampage) on any grey cure countries. If you cannot use the little fist, migrate a colony to that country and try again.

Build your DNA Points to (75)

(Global Action Message should have come up by now)


  • Primal Hunt
  • Weapon Creation
  • Cold Resistance 2

If you encounter drones, or new research facilities, pause your game, Migrate from drones, or use the little fist on the research facilities. Don't forget to unpause your game.

Keep watching for the lethal symptoms, you don't want it to be too lethal before everyone is infected.

Continue to look around the map for cure/research facilities, they will keep coming.


Once you receive the "There are no healthy people left in the world message" Use your DNA points in Symptoms to make it as deadly as possible. Continue to use your DNA points, you will have tons and tons of them to do this.

Remember, Keep migrating out of drone strikes and keep destroying those research/cure facilities.

In the next several minutes you will be migrating and destroying research facilities. It is very easy to lose track of the cure progress. Just remember to pause the game if things get out of hand.


Apes have taken over and the Humans are dead!

It took me roughly 1000 days to complete the tutorial, How long did it take you?

I want to know if you mixed it up a little or if you have an easier way. Leave a comment below.


Leave a Comment With...

The amount of days it took you to win. I wanna know.

Planet of the Apes Trivia

For each question, choose the best answer. The answer key is below.

  1. What year did the original Planet of the Apes movie come out?
    • 1968
    • 1988
    • 1948
    • 1978
  2. Who coined the phrase "Take your stinking paws off me, you damned dirty ape."
    • Scarlett Johansson
    • Shia LaBeouf
    • Charlton Heston
    • Tom Hanks
  3. What is Planet of the Apes about?
    • Giant Turtles take over the earth and only apes have the know-how to destroy them.
    • An astronaut travels through time and Apes have taken over the world.
    • An astronaut travels through time and David Bowie has a cult that has taken over the world.
    • The starship enterprise travels through the Game of Thrones wormhole, and find an Ape floating in space.

Answer Key

  1. 1968
  2. Charlton Heston
  3. An astronaut travels through time and Apes have taken over the world.

© 2014 Ashleign


ori on August 23, 2020:

not even 900 days

Taylor Tomlinson on July 02, 2020:

I never saw any drones, and only had 1 research facility, and it was nearthe very beginning. It is very confusing indeed how this all works, but the tutorial worked wonders. Thanks.

Quintavius williams on March 10, 2020:

1274 days

Followed each step

Cure progress 36%

All 5 biohazards

Score 144460

MRJ1997 on February 29, 2020:

1,084 days, 26% cure progress, and 209,960 score. First try.

Sodax on February 25, 2020:

958 days, 39% cure, 154600 score on this strat (first try on norm) it's rly good c:

Hellno15 on February 08, 2020:

1007 days with 45% cure and 68490 score

ekil12/Nekiś on January 24, 2020:

966 days, 43% cure, 57920 score

Erick on January 01, 2020:

1342 days

Idris on October 11, 2019:


Ashlynn Stowe on September 27, 2019:

1133 Days, 20% cure, 5/5 biohazards and 247610 score. First time trying and beat it!!!

VincentVMarshburn on August 31, 2019:

Fantastic guide. I followed it to the letter and won on the first try. I think this was my favorite plague. (Tip:don't forget to devolve those lethal symptoms.)

1337 day (I am serious; I have the screenshot to prove it)

44% cure

90400 score

4 biohazards

Genes: Metabolic Hijack, Native Biome, Extremophile

Deane on July 06, 2019:


Near the end I evolved the full path of neural enhancement and created a planet of the apes

Jerome L Zaha on June 11, 2019:

1456. Humans die. 77% cure. But the first time I beat it. Thanks

Donk on March 16, 2019:

Couldn't follow the guide exactly because the stupid lethal mutations kept happening, but I just stopped looking at the guide after the horseback riding and i just winged it from there, but I beat it in 1196 days and it works great, thanks

Countrybass70 on March 03, 2019:

Took longer than 1000 days.

1508 Days

14% Cure

237860 total score

Also I gave it a stupid name, "Monkey Time"

will on March 02, 2019:

using this guide i got 970 days

meilan on February 28, 2019:

I managed to beat Simian Flu on Brutal with this guide! Works perfectly. Thank you!!!

Effigy on November 09, 2018:

Great guide! Siemian Plague has been kicking my butt for a while now. It took 1113 days to complete the game and not one research facility spawned.

Jayne on September 12, 2018:

Time: 840 days

Cure progress: 22%

Score: 40390

Used Metabolic Hijack, suppression and extremophile.

Jacob on August 21, 2018:

991 days 82770 score with this tut ty

Bronzeborg on August 20, 2018:

stupid neuro enhancer keeps evolving for me... once twice in a row! had to spend 50 points to devolve it.

Boi on July 13, 2018:

Took me 1988 days

Blacephalon on July 07, 2018:

me: sees tutorial to start in Indonesia

*internal, but extremely high mental excitement*

dude. I live in Indonesia.

Eric on July 02, 2018:

Wow- this worked incredibly well. I've played it through several times, and this time I racked up a score of 207480, and wiped out humanity in 1063 days.

Unknown on June 10, 2018:

Thank you very much for your tutoriel it really helped me

Calliare on June 10, 2018:

Yes it does work lol

You must be doing something wrong if it failed for you. This is literally the best guide there is.

Ethan Marcello on May 24, 2018:


It does not work at all.

Apparently I need to keep my eye on the cure and somehow get DNA points out of nowhere to by reshuffles and hardening on top of your crap guide. I tried it 8 times and it did not work.

L Bigelow on March 30, 2018:

1017 days, score 61,000, 4 biohazard, cure progress 19%... Named it CHPotA 13 (Charlton Heston Planet of the Apes 13... hehe) followed ur guide to the letter and it was easy, once it had infected everyone, made it as lethal as possible ASAP. I had to VERY proactively run from drones and destroy research facilities as soon as they cropped up. had to pause a lot so it didn't get away from me. Thanks for the guide, helped me thru this one and necroa virus

Lachlan on February 20, 2018:

Took me 1068 days with 27% cure completion and a score total of 122740

Ashleign (author) on January 25, 2018:

I try not to make recommendations, the reason I chose to do this without them, is that not everyone has them unlocked. Metabolic HiJack is my favorite because I am lazy.

leo on January 23, 2018:

hi i just wanna ask a question but what are the suggested genes you recommend?

Mink on January 13, 2018:

995 days

Cure 41%

Instead of doing formites 2 I did air 1 but added formites later. That helped spread a lot faster than my first try. I didn't even try to get formites 3

redwolftrash on January 02, 2018:

research facilities began WAY too early for me to properly upgrade fomites and infection spreading transmissions like air and water; as a result i had stupid apes when i should've had smart ones that could migrate and since the virus kept mutating i wasted most of my DNA devolving that neuro-enhancement symptom! now the virus i made was cured and i lost all access to the simulation since i have to defeat every illness of brutal to unlock it (not wasting anymore money on the game).

Johnny on November 05, 2017:

In the little quiz, the actor who spoke the phrase was tom felton

Jacob on October 29, 2017:

DNA Sequence: Complex

Time: 1030 Days

Cure Progress: 36%

Score Total: 11890

Kristina on October 27, 2017:

Sinister Primate: 1465 Days, 62% Cure, Score of 38910, 4/5

Carly on September 09, 2017:

Named mine MNKY-BIZ. Not very creative, but made me giggle.

Dia on August 29, 2017:

1435 days cure was at 9% 5 stars 356360 for points loved the tutorial

Tom on August 27, 2017:

1230 Days, 28% Cure, 4/5 Stars with 86850 Score

Sergiu on August 05, 2017:

1070 days. Thank you very much!

Monkey Madness on July 28, 2017:

Took me 1002 days

Cure was at 60%

Anonymous on July 08, 2017:

1030 days, 26% cure, 198450 score with 5 bio hazards on first attempt using this strategy. Works very well!

Robyn on July 05, 2017:

Adjusted it a bit and managed to win with 5 biohazards and a 103290 score, but it took 1407 days and the cure got to 45%. Great tutorial!

Poop Dick on June 22, 2017:

My disease, called Poop Dick, wiped out humanity in 1308 days

Vitiate on June 19, 2017:

931 days with this tutorial, cure at 11%, great guide and a lot of fun to play.

That Girl with the Metal Panties on June 04, 2017:

It workd!

Here, have a piece of pie.

Acey76 on April 30, 2017:

could you do a walkthrough of the Shadow Plague???

Chris on April 26, 2017:

1083 days, 39% cure, 136980 score. Youre a lifesaver.

Dom on April 09, 2017:

1036 days...very effective

jordan on February 22, 2017:

took me 1295 days.

Tom on February 16, 2017:

Wow, this works well!

914 days

22% cure progress

5 stars and a score of 217,860!

Arghtonyrgoth on February 12, 2017:

1123 days and 4 biohazard signs. Made me wanna watch 'rise of the planet of the apes' again

Someone on February 03, 2017:

Named mine death :P

Drugs on January 19, 2017:

1042 days

35 percent cure progress

5 biohazerd symbols

Total score 138400

My best score Yet! And i have played this for about three or four years thank you!!

Drugs on January 19, 2017:

This is basicly the hardest plague in the game

Ben on January 14, 2017:

1096 days

37% cure

5 star things

Thank you

Neurax on December 27, 2016:

Amazing tutorial, also worked on brutal.

Ashleign (author) on December 20, 2016:

Oh my god. I tried it for the first time the other day. It's gonna take me a little while longer to figure it out. Be sure to follow!

Mike Hudy on December 05, 2016:

Any chance of a Shadow Plague tutorial?

Lolmg on December 05, 2016:

I mmm.. not sure if this works

Laukes on November 29, 2016:

Your guide was perfect, ty!

107700 Score in 1030 days and only 34% cure. Best game i had till yet!

Rodan Grif on November 01, 2016:

Followed it exactly and still lost. Was this made for the mobile version or pc version?

Totally Not an Ape on October 08, 2016:

What genes do we use?

Anonymous on September 17, 2016:

I named my disease Ape$h*t

Ashleign (author) on September 15, 2016:

You are most welcome all of you. Thank you for visiting / following.

Plague God on September 13, 2016:

Thank you so much Ashleign, you have helped me so much with your tips, I really appreciate it. P.S. Did you know that with these tips, I have finished brutal on every single plague, including simian flu and nercroa virus and nearax worm with the help of your tips. THANKS ASHLEIGN!!

PlagueGod on September 13, 2016:

Thank you so much Ashleigh, I really appreciate your amazing tips, they are the best! Thanks Ashleign! P.S. Just so you know, I have completed all of the plagues, even simian flu, necroa virus and nuerax worm on brutal because of your tips, but you have to modify them a little bit. THANKS!

Cragon on August 12, 2016:

Thanks, I overlooked the colony importance. Once at least 3 are working it's really hard not to have enough points to go in any direction you want. I completed normal with ease with 3 colonies. I am sure brutal will need more.

Anon on June 27, 2016:

964 days

World killer on June 14, 2016:

1443 days

Raven on June 10, 2016:

Thanks 923 days =)

Ava on April 21, 2016:

934 days, cure progress 26%, 4 stars, score of 44470

This is the best tutorial I've seen :D

Emma on March 26, 2016:

1010 days

Wtf on March 13, 2016:

866 days!

Ashleigh on February 21, 2016:

This helped so much..I screwed up so badly the first few times..haha.. Took 1482 days for my simian flu to destroy all humanity. Next time I'll try for a better score. Thanks again!!

ShanerX on February 15, 2016:

Excellent once again, 1088 days! Was hard first 2 times, this guide made it simple, gdamn h0w I messed up the first couple times!

Epix Jackasaur on February 08, 2016:

988 days

Cure 25%


Bossin' guide

Rozack on February 05, 2016:

I call it sans

Care on January 23, 2016:

Found the solution. Click on "ape view" on the ape icon in the bottom left corner of the screen. It will show you when countries turn bright green, at that point you can create a colony. The rampage "fist" is used in places you already have a colony, instead of blue bubbles (cure bubbles in most games) it shows the gen sys labs. You use ape rampage/ the fist to "pop" them like you would cure bubbles. Hopefully that makes sense to those who were having the same issue on android. I won on my second try.

Care on January 23, 2016:

I'm having the same issue on android phone/ tablet as several others. I can't move the colonies, or create colonies, or get the fist to work. Occasionally it works to create them, but most of the time it does nothing, and I only seem to be able to create colonies when it does work that are right beside colonies that already exist, making it impossible to infect across the map. I've not been able to migrate at all. Anyone found a solution for this?

giucolson on January 10, 2016:

211940 points, cure at 26% and I made it in 1086 days.

I had so many DNA points that at the end I unlocked all of the symptomps. Great tutorial!

Damian on December 11, 2015:

This flu is realistically the easiest. Great Tutorial though:)

RafKimeon on November 07, 2015:

Oh, I wouldn't say what I said without trying multiple times. I still had to change a few things, like put out a lot of colonies, and also grind in Casual a little to get some of the genes.

GeneralCow on November 06, 2015:

I just used this tutorial and beat Normal like it was nothing. 11/6/2015

Every game has some luck factor in it, so don't give up with this guide after the first try.

RafKimeon on November 04, 2015:

I agree with the previous poster that this tutorial is ineffective. Maybe they changed something to make this harder? I think it does need to be revisited. :-(

GamerVsGaming123 on October 22, 2015:

BS doesnt work I did every thing he did and it didnt work

Guy on July 20, 2015:

Thank you! If i dident find you i would still be on fungus or deleted the game. So thank you for the beast tutorials on the internet ashleign.

Under a Graveyard Sky on June 30, 2015:


1141 Days, 40% Cure, Score 153,260

This tut was superb. Just a few tweaks and all was golden.

Gabriel on May 24, 2015:

1128 Days with 37% cure. Thank you!

Chance on March 27, 2015:

Thank you for this! I have been trying to beat this one for a week and couldn't. With your help I got 799 days. You rock!

RIO on March 18, 2015:

Hey who say it doesn't not work cause the dna not enough.hah,screw that cause i got the cheat unlimited dna and its the new version

Burt on March 03, 2015:

Thanks to your tutorial, not only did I manage to beat this level, but with an amazing score of 204110! Five stars!

Time: 1097 days, cure progress: 28%, Complex. Every symptom by the end except for neuro-enhancement.

Thanks for all your great tutorials. Extremely helpful!

BR on January 05, 2015:

DNA Sequence = Complex

Time = 856 days

Cure Progress = 21%

Total Score = 16,040 (3 of 5 symbols filled)

Alex Marquette on December 29, 2014:

1036 days and missed out on like 3 symptoms and the cure was at 46% complete

Hexenhammer on December 18, 2014:


Just wanted to say that this guide worked flawlessly (with slight fexibility ofc) on highest difficulty, over 142k points with my first touch with this game thanks to you :D

km373 on December 15, 2014:

Days: 1085

Cure: 38%

Score: 148 530

Symptoms: All without Neuro-Enhancement

Madgeek1450 on December 07, 2014:

Followed this, 1st playthrough on Normal was 1034 days, 20% cure, 5 stars @ 220,490 points. Thanks!

Michael Due Hermansen on December 06, 2014:

Hi love your guides ;) very useful :D did is as you did, and got 5 stars :D it somehow took the stupid humans a lot longer discovering me, so guess i was lucky :)

NitroQueen on December 03, 2014:

Ok maybe its just me but I cannot seem to figure out how to "move the colonies around" once I place a colony someplace. How do I move them? Also couldn't figure out how to get away from the drones. Do I use the Ape Rampage wherever I see one flying around or what? Not sure if it matters but I am playing the game on mobile. Any suggestions? Every other tutorial of yours has worked for me 1st try. This is the 1st time I got stuck. Help plz? Thanks!

Armageddon1990 on November 30, 2014:

Free version, 1054 days, cure 37%, score 36640.