Plague Inc. Evolved: Simian Flu on Normal

Planet of the Apes Trivia


Take your stinking paws off me, you damned dirty ape!

So it seems like yesterday I crawled out bed and ran down stairs at 10pm at night to see my father watching Planet of the Apes. Of course back then we had this ancient technology called VHS. Kids today of course have no idea what that is, unless their parents were 80's babies and still have old copies of the Lion King.

No the day of recording over crappy movies to record all your favorite shows is over unfortunately. With the end of VHS and the move into DVD which will soon be replaced by BluRay or whatever else those squirrelheaded tech gurus over in silicon valley come up with next.

Here we have the Simian Flu.. A Plague that you will want to start in the Country of Indonesia.

This one is a lot different than the others. I am just going to let you know, you may encounter a moderate amount of BS in this tutorial.

Take a deep breath

Let's get this thing started here guys. We are venturing into unknown territory. Plague Inc is renowned for it's casual gameplay style. Not anymore. Simian Flu is going to take some serious attention and ability to react quickly.

Allow all Symptom mutations except: Neuro-Enhancement 1 and except: Lethal Symptoms

Our Mission:

Infect the entire world. Allow Apes to take over. Kill the entire world. Sounds simple right? Wrong.

Start in Indonesia

Build your DNA Points to (20)


Simian Neuro-Genesis

Organised Travel

Build your DNA Points to (15)


Ape Colonies

Use Your Ape Colony ability on Indonesia

Build your DNA Points to (16)


Cognitive Shift

Ape Rampage

Build your DNA Points to (30)


Fomites 1

Fomites 2


Cold Resistance 1

Once Indonesia's Ape Colony Bar is full, use Migration to move them to another country. (doesn't matter which)

Create another Colony in another Country (Doesn't matter which just not Indonesia)

Build your DNA Points to (40)



Drug Resistance 1


Inter-Genus Dissemination 1

Create another Colony in another country (Doesn't matter which)

Build your DNA Points to (50)


Fomites 3

Air 1

Water 1

Sebaceous Excretion

Build your DNA Points to (60)


Primal Awareness

War Paint


Horseback Riding

This would be a good time to pause your game and move your colonies around. You want to spread them across the map. (This is for when the research facilities come into play) Spread them out but not too far apart.

Unpause your game

You should see any moment now, little grey cure blocks they will have a beaker on them.

Build your DNA Points to (80)


Hominidae Bridge

Air 2

Water 2

Now, use your little fist or (Ape Rampage) on any grey cure countries. If you cannot use the little fist, migrate a colony to that country and try again.

Build your DNA Points to (75)

(Global Action Message should have come up by now)


Primal Hunt

Weapon Creation

Cold Resistance 2

If you encounter Drones, or new research facilities, Pause your game, Migrate from drones, or use the little fist on the research facilities. Don't forget to unpause your game.

Keep watching for the lethal symptoms, you don't want it to be too lethal before everyone is infected.

Continue to look around the map for cure / research facilities, they will keep coming.

Once you receive the "There are no healthy people left in the world message" Use your DNA points in Symptoms to make it as deadly as possible. Continue to use your DNA points, you will have tons and tons of them to do this.

Remember, Keep migrating out of drone strikes and keep destroying those research/cure facilities.

In the next several minutes you will be migrating and destroying research facilities. It is very easy to lose track of the cure progress. Just remember to pause the game if things get out of hand.


Apes have taken over and the Humans are dead!

It took me roughly 1000 days to complete the tutorial, How long did it take you?

I want to know if you mixed it up a little or if you have an easier way. Leave a comment below.

Be sure to subscribe to me on YouTube as well. A follower here is great too!

Monkey Love started this.

What did you name your Simian Flu?

Did this damned dirty tutorial work for you?

  • Yes. I love you so dearly.
  • No, but I am going to try again, because I probably skipped ahead.
See results without voting

About Ashleign aka ChillBilly

Hey guys, I'm ChillBilly aka Ashleign. I have been playing video games for more than 20 years. I enjoy a good bit of strategy style games mixed with online economies. MMOs are my specialty, but I do enjoy all kinds of games. My experience with Plague Inc. started when I picked up the game on my mobile phone. I immediately was hooked due to a long interest I have had in biology. I posted my first tutorial here on hubpages and it was so popular I decided to make more.

I love helping people, and when I receive good comments and compliments, I feel that I have accomplished something.

Be sure to leave a comment with...

The amount of days it took you to win. I wanna know.

More by this Author

Comments 78 comments

Totally Not an Ape 2 weeks ago

What genes do we use?

Anonymous 5 weeks ago

I named my disease Ape$h*t

Ashleign profile image

Ashleign 6 weeks ago from Alabama Author

You are most welcome all of you. Thank you for visiting / following.

Plague God 6 weeks ago

Thank you so much Ashleign, you have helped me so much with your tips, I really appreciate it. P.S. Did you know that with these tips, I have finished brutal on every single plague, including simian flu and nercroa virus and nearax worm with the help of your tips. THANKS ASHLEIGN!!

PlagueGod 6 weeks ago

Thank you so much Ashleigh, I really appreciate your amazing tips, they are the best! Thanks Ashleign! P.S. Just so you know, I have completed all of the plagues, even simian flu, necroa virus and nuerax worm on brutal because of your tips, but you have to modify them a little bit. THANKS!

Cragon 2 months ago

Thanks, I overlooked the colony importance. Once at least 3 are working it's really hard not to have enough points to go in any direction you want. I completed normal with ease with 3 colonies. I am sure brutal will need more.

Anon 4 months ago

964 days

World killer 4 months ago

1443 days

Raven 4 months ago

Thanks 923 days =)

Ava 6 months ago

934 days, cure progress 26%, 4 stars, score of 44470

This is the best tutorial I've seen :D

Emma 7 months ago

1010 days

Wtf 7 months ago

866 days!

Ashleigh 8 months ago

This helped so much..I screwed up so badly the first few times..haha.. Took 1482 days for my simian flu to destroy all humanity. Next time I'll try for a better score. Thanks again!!

ShanerX 8 months ago

Excellent once again, 1088 days! Was hard first 2 times, this guide made it simple, gdamn h0w I messed up the first couple times!

Epix Jackasaur 8 months ago

988 days

Cure 25%


Bossin' guide

Rozack 8 months ago

I call it sans

Care 9 months ago

Found the solution. Click on "ape view" on the ape icon in the bottom left corner of the screen. It will show you when countries turn bright green, at that point you can create a colony. The rampage "fist" is used in places you already have a colony, instead of blue bubbles (cure bubbles in most games) it shows the gen sys labs. You use ape rampage/ the fist to "pop" them like you would cure bubbles. Hopefully that makes sense to those who were having the same issue on android. I won on my second try.

Care 9 months ago

I'm having the same issue on android phone/ tablet as several others. I can't move the colonies, or create colonies, or get the fist to work. Occasionally it works to create them, but most of the time it does nothing, and I only seem to be able to create colonies when it does work that are right beside colonies that already exist, making it impossible to infect across the map. I've not been able to migrate at all. Anyone found a solution for this?

giucolson 9 months ago

211940 points, cure at 26% and I made it in 1086 days.

I had so many DNA points that at the end I unlocked all of the symptomps. Great tutorial!

Damian 10 months ago

This flu is realistically the easiest. Great Tutorial though:)

RafKimeon 11 months ago

Oh, I wouldn't say what I said without trying multiple times. I still had to change a few things, like put out a lot of colonies, and also grind in Casual a little to get some of the genes.

GeneralCow 11 months ago

I just used this tutorial and beat Normal like it was nothing. 11/6/2015

Every game has some luck factor in it, so don't give up with this guide after the first try.

RafKimeon 11 months ago

I agree with the previous poster that this tutorial is ineffective. Maybe they changed something to make this harder? I think it does need to be revisited. :-(

GamerVsGaming123 12 months ago

BS doesnt work I did every thing he did and it didnt work

Guy 15 months ago

Thank you! If i dident find you i would still be on fungus or deleted the game. So thank you for the beast tutorials on the internet ashleign.

Under a Graveyard Sky 16 months ago


1141 Days, 40% Cure, Score 153,260

This tut was superb. Just a few tweaks and all was golden.

Gabriel 17 months ago

1128 Days with 37% cure. Thank you!

Chance 19 months ago

Thank you for this! I have been trying to beat this one for a week and couldn't. With your help I got 799 days. You rock!

RIO 19 months ago

Hey who say it doesn't not work cause the dna not enough.hah,screw that cause i got the cheat unlimited dna and its the new version

Burt 20 months ago

Thanks to your tutorial, not only did I manage to beat this level, but with an amazing score of 204110! Five stars!

Time: 1097 days, cure progress: 28%, Complex. Every symptom by the end except for neuro-enhancement.

Thanks for all your great tutorials. Extremely helpful!

BR 22 months ago

DNA Sequence = Complex

Time = 856 days

Cure Progress = 21%

Total Score = 16,040 (3 of 5 symbols filled)

Alex Marquette profile image

Alex Marquette 22 months ago

1036 days and missed out on like 3 symptoms and the cure was at 46% complete

Hexenhammer 22 months ago


Just wanted to say that this guide worked flawlessly (with slight fexibility ofc) on highest difficulty, over 142k points with my first touch with this game thanks to you :D

km373 22 months ago

Days: 1085

Cure: 38%

Score: 148 530

Symptoms: All without Neuro-Enhancement

Madgeek1450 23 months ago

Followed this, 1st playthrough on Normal was 1034 days, 20% cure, 5 stars @ 220,490 points. Thanks!

Michael Due Hermansen 23 months ago

Hi love your guides ;) very useful :D did is as you did, and got 5 stars :D it somehow took the stupid humans a lot longer discovering me, so guess i was lucky :)

NitroQueen profile image

NitroQueen 23 months ago

Ok maybe its just me but I cannot seem to figure out how to "move the colonies around" once I place a colony someplace. How do I move them? Also couldn't figure out how to get away from the drones. Do I use the Ape Rampage wherever I see one flying around or what? Not sure if it matters but I am playing the game on mobile. Any suggestions? Every other tutorial of yours has worked for me 1st try. This is the 1st time I got stuck. Help plz? Thanks!

Armageddon1990 23 months ago

Free version, 1054 days, cure 37%, score 36640.

Synien 23 months ago

1224 days and 5 stars. Thank you very much for the guide.

Tee 24 months ago

How in the world do we migrate the colonies on the mobile version? All of your tutorials have helped me on first tries..(thank you for that! Lol) But this? I'm stuck cuz I can't figure out where the Ape colony bar is, or how to migrate. Can you plz help with that? I can't seem to find answers anywhere on the net. Thanks!

IRONEMIKE 24 months ago

734 days with 200 DNA Genes left works well

Alexander 24 months ago

First Attempt:

968 days

20% cure

5 Stars, score 338,660

On Normal.

I could've probably finished it even earlier, had I gone up the Neural Enhancement symptom road the moment everyone was infected. You see, as it turns out, the first neural enhancement makes humans smarter, the second even smarter, the third EVEN smarter with a small chance to die, and the fourth makes them go BRAIN DEAD.

In other words, it is the 'Annihilation Gene' of the Simean Flu.

Thomasds 24 months ago

Good tutorial!

have done it in 1025 days!

GT 24 months ago

First Attempt:

1160 Days

52% Cure Progress

113,640 Score

Saul Goodman 2 years ago

What genetic modifications did you use?

Shawn 2 years ago

thanks for this... Beat it in 995 days!

ASC 2 years ago

Hi. Can you do the black death scenario next? It would help me a lot :)

James 2 years ago

My flu killed all its hosts. :(

Mikael 2 years ago

909 days, 5 stars! Thanks so much for the walkthrough, this worked out even better than the Necroa :)

Annabelle 2 years ago

1478 Days, 210670 score. 37% cure progress

Chris 2 years ago

This guide worked for me on my first try, but I had a really weird occurrence early on. I followed your instructions and attempted to migrate my apes from Indonesia to the Philippines. However, when the migration completed, all of the apes were dead! I was lucky enough that some apes in SE Asia had already become intelligent, and I just formed a colony there. But yeah, that was a bit problematic.

Napoleon 2 years ago

1033 days

58% cure

AJL 2 years ago

Did it in 1155 days, named my Simian Flu Abbott (Australians will get the comparison to our ape-like Prime Minister).

Have won on Brutal twice, but have lost several times. For some reason it often goes hyper aggressive with the labs and drones much earlier than expected.

Meghan Helmich 2 years ago

Did it in 1407 days, 4 stars, 48690 final score!

Rachel Cook 2 years ago

I can't get neuro-enhancement to devolve!

grenadeh 2 years ago

The fact that you call this game casual is ridiculous. It's insanely hard depending on difficulty.

Ashleign profile image

Ashleign 2 years ago from Alabama Author

Haha, been there! Glad you had success!

Tim Sutherland 2 years ago

Brutal, 50K 1,743 days, 70% cure. Spent the last 10 minutes of the game devolving everything as Canada and Greenland had a few hold outs. I had the kill people to slow the cure down as I had run out of other means to slow it.

AeroAviation 2 years ago

Beat it on my 3rd attempt with this guide, My first 2 attempts failed because I was not attacking labs correctly and going for deadly symptons too early...

Rebecka 2 years ago

Thanks for the tutorial, worked great for us! Only mixed it up a little once we were done with the instructions in your tutorial, increasing infectiveness and so on. Finished in 983 days, cure 40%, score 124980 and 5 stars.

mike 2 years ago

Thanks for the tutorial, had been doing a very similar plan but starting in England but kept getting close but kept losing. Score of 36650 in 1044 days with 4 stars.

Jona 2 years ago

thanks i mixed up, ape can evolve first too , faster but lower score

Dan 2 years ago

15%cure 1066 days and 16550 score, thanks :)

bengast 2 years ago

1074 days 43% cure 5 star 13440 score :')

ThePsycho1927 2 years ago

Mr viking

Wow such angst

so edge

Much rebel


Arcturus 2 years ago

First try with the guide: 1079 Days and 5 stars / 195280

Thanks for the guide

Ashleign profile image

Ashleign 2 years ago from Alabama Author

It should be the same. You should be able to push the ability and then touch on the colony you want to move. Hope this helps.

Jeff 2 years ago

Yeah the mobile version I am having issues with figuring out how to migrate the colonies to prevent the drones from snuffing them out.

Ashleign profile image

Ashleign 2 years ago from Alabama Author

I'm not sure. I haven't tried the mobile version yet.

Jeff 2 years ago

Any idea what the Ape colony bar is like in the Phone app?

mafrizor 2 years ago

2nd try, 1028 days, 142,080 score 5 stars, 34% cure , ez pz , thanks for the guide.

Ashleign profile image

Ashleign 2 years ago from Alabama Author

Thank you Jinx. That's the thing about all Plague Inc. Games. My tutorials take into account that if you move too fast, you are going to generate mutations. Some of us are unlucky enough to get the same mutations over and over. You are so right.

Jinx 2 years ago

This tutorial worked really well for me. I destroyed humanity in 1270 days, with cure progress at 45% making for a 70620 4 star score.

This tutorial DOES WORK. It just takes some patience to get points at first. And there is a fair amount of luck as well. I was lucky enough to have Neuro-Enhancement 1 evolve only /once/ on me and only a couple lethal ones before there were no more healthy people left. I'd be surprised if I'm that lucky again when I play it again.

Ashleign profile image

Ashleign 2 years ago from Alabama Author

See the video.

Chad 2 years ago

Doesn't work. Takes way too long to build dna points using that tutorial. I've completed normal difficulty by spending points on transmission and abilities first, then worry about building the army of apes. Otherwise you will take forever to do it the way suggested in the tutorial.

Megan 2 years ago

It didn't work for me and I went exactly how the tutorial told me to go, twice. I didn't have enough DNA points for many of the things on this list although I saved up the amount mentioned. My game might have randomly generated some things that caused the cure to increase quicker but I tried it twice and failed both times. I even let all the symptoms develop. The one that increases intelligence in humans evolved FOUR times for me. It was definitely the most annoying aspect of this challenge.

aule 2 years ago

thank you great guide, i failed first time, because i made rookie mistake and used all my DNA on symptoms so i had no DNA to beat the crap out of labs. and before i knew it they drones all my apes and the cure was developed

Undead Brad 2 years ago

Sweet, this helped a lot as I kept getting killed by drones before. I have now beaten it in 996 days :D

    Sign in or sign up and post using a HubPages Network account.

    0 of 8192 characters used
    Post Comment

    No HTML is allowed in comments, but URLs will be hyperlinked. Comments are not for promoting your articles or other sites.

    Click to Rate This Article