No, you can not defeat him. If you shoot enough times in the store or steal an item, he will shoot at you until you leave the store. Once the shopkeeper leaves, he will be gone for the rest of this floor, and will not show up in future floors.
What does Beast Mode do in Enter the Gungeon?
Copyright © 2018 HubPages Inc. and respective owners. Other product and company names shown may be trademarks of their respective owners. HubPages® is a registered Service Mark of HubPages, Inc. HubPages and Hubbers (authors) may earn revenue on this page based on affiliate relationships and advertisements with partners including Amazon, Google, and others.
Copyright © 2018 HubPages Inc. and respective owners.