How to Beat Plague Inc. Prion on Normal

Updated on March 6, 2016
Ashleign profile image

mysticalnerdtv on instagram mysticalnerd on twitch Ashleign is a woodworker and yard enthusiast.

Beating Prion on Normal

This tutorial, while similar to the Virus tutorial I posted, is a little different in the way you go about the game. Please make sure you read the steps carefully and follow them to a T. If you have come this far, you probably know the game pretty well now. Let's get this started!

First things first: you are allowing symptoms to mutate.

  1. Start your virus in South Africa.
  2. Build DNA points to 50.
  3. Get Air Resistance 1.
  4. Get Air Resistance 2.
  5. Get Water Resistance 1.
  6. Get Blood 1.
  7. Build DNA Points to 50.
  8. Get Water Resistance 2.
  9. Get Drug Resistance 1.
  10. Get Heat Resistance 1.
  11. Get Cold Resistance 1.
  12. Build DNA Points to 100.
  13. Get Drug Resistance 2.
  14. Get Heat Resistance 2.
  15. Get Cold Resistance 2.
  16. Get Genetic Hardening 1.
  17. Build your points to 100 or until everyone is infected.
  18. Once you have either reached 100 points or everyone is infected, put points into symptoms leading to Total Organ Failure. Spend your remaining points into anything else that is lethal. Don't worry about the cure. However, if you want you can spend any additional points to slow the cure for a higher score.

Update to Tutorial

I have noticed there being a change in the current tutorial as it stands.

All you have to do is put your additional points into genetic reshuffle 1 and genetic reshuffle 2 to prevent the cure from going 100%

Video: Prion on Normal Walkthrough

Updated: My stats as of 3/27/2014.
Updated: My stats as of 3/27/2014.

About the Author

Ashleign is my alias and a character I play on the internet. I have used this nickname for several years. I have worked in IT for about four years. Before that, I worked as an EMT in EMS. There, I drove the ambulance mostly, but I can say that I was in the room while a life was actually being saved—that was a cool thing to see. Bless our troops, fire, police, and EMS workers they have an incredibly hard job, and I love them with every bit of my heart. Especially the police.

I've been working very hard on these tutorials for you and appreciate any and all feedback you want to provide. Please let me know how you did, I would love to hear from you!

Please Answer the Poll

Did this tutorial work for you?

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Questions & Answers

  • This didn't work. I ended up with all the hosts being killed but I lost because there were still healthy people. What happened?

    Prion changes is the short story. Sometimes the tutorial works, sometimes it doesn't. Try again see if you have success if not.. Minecraft Mobile is fun.

Comments

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    • profile image

      nikoskoub 

      3 days ago

      Doesn't work

    • profile image

      CoCoGamer 

      3 weeks ago

      What do you mean by "air/water resistance"? Do you mean transmition?

    • Ashleign profile imageAUTHOR

      Ashleign 

      5 weeks ago

      it happens.

    • profile image

      Panda 

      6 weeks ago

      Instruction not clear, ended up making earth flat

    • profile image

      Flerovium 

      2 months ago

      I Melted In this prion achoochooness because theyre like killing me like 2016

    • Ashleign profile imageAUTHOR

      Ashleign 

      2 months ago

      Way to go!

    • profile image

      Adriana 

      2 months ago

      Finally beat it after 4 tries although I did a few things differently...

      - Get the gene that allows you to get DNA points when devolving symptoms and the darwinist gene so everytime a new symptom mutated I devolved it immediately.

      - I got to step 18 with everyone infected and 89 DNA points after already buying genetic reshuffle I & II so I waited and kept devolving symptoms and collecting DNA until it got to 98.

      - Around this time governments randomly find out about the disease but it's considered not dangerous yet.

      - Devolve all the transmissions and abilities except genetic reshuffle.

      - Buy symptoms to get to total organ failure.

      - A cure will immediately begin to be researched. You will have no DNA and people will die too slow.

      - Devolve al non-lethal symptoms. When enough people die, you will begin to get additional DNA points.

      - Keep evolving the most lethal symptoms you can afford. As soon as you get enough DNA points buy a new symptom.

      - Eventually they will stop researching the cure and everyone will die...I my case the cure got to 97%....close call

      I hope this helps :)

    • profile image

      CanadianGeese 

      3 months ago

      Should i use any genetic codes if so are they specific or do i just disable my genetic codes that i have applied

    • profile image

      Cheese 

      3 months ago

      I know im late but is resistance transmission

    • Ashleign profile imageAUTHOR

      Ashleign 

      3 months ago

      Eeek.. Glad you won though.

    • profile image

      3 months ago

      barely won, cure was at 98% when the game ended

    • Ashleign profile imageAUTHOR

      Ashleign 

      4 months ago

      Dang. Okay, so is there a point where all is swell? It's working great then it all goes to hell? Help me help you.

    • profile image

      Me 

      4 months ago

      Sorry. Tried it over ten Times. Doesbt work at all

    • Ashleign profile imageAUTHOR

      Ashleign 

      4 months ago

      Hmm.. Sometimes you have to do this tutorial a couple of times. This is one the levels that changes. Try it a third time, and if that doesn't work, we will talk it out.

    • profile image

      Kalko 

      4 months ago

      I can't infect Greenland... I tried it 2 times and every time the whole world gets infected and dies except for Greenland. How do i fix this?

    • Ashleign profile imageAUTHOR

      Ashleign 

      4 months ago

      Yea, unfortunately, this is one of those you gotta go at it once or twice or six times. I've re-written it a time or two, but it just seems to be a situational one.

    • profile image

      JGL 

      4 months ago

      Yeah honestly this doesn't seem to work at all except in the case of infecting everyone. Research just shoots up like a bloody rocket.

    • profile image

      deucaliakat 

      4 months ago

      worked perfectly for me, boosted a few "infection" symptoms to infect everyone faster after step 12. needed both reshuffles, but ended the game 831 days cure 56% complete

    • profile image

      Tg 

      4 months ago

      This doesn't seem to work very well anymore.

      I've tried several times. Everytime I had everyone infected and people dying from organ failure before cure research starts. Despite devolving the unnecessary stuff I never regained enough DNA to do any genetic reshuffling. Cure research even seems to speed up.

      Best result was 2 billion dead.

    • profile image

      Amazingamer01 

      4 months ago

      What is air resistance?

    • profile image

      James T 

      4 months ago

      Dosent work at all. Tried 4 times even without mutations

    • profile image

      V. Fisheri 

      4 months ago

      Following this to a T did not work for me any of the times I’ve tried, I’m going to try again but without allowing persistence of mutations and see if that works.

    • profile image

      Slatt316 

      4 months ago

      Tried this method three times and didn’t work

    • profile image

      Nightmare Helpy 

      5 months ago

      I tried this and it worked Thank you

    • profile image

      warpaint408 

      5 months ago

      Comes down to the crunch but works so well! 993 days with 76% cure! Thank you!

    • profile image

      5 months ago

      It was a close call- the cure was 97% complete

    • profile image

      Valhalla 

      5 months ago

      So I have an addendum to your guide that worked for me. Instead of allowing mutations, I devolved everything except for coughing and that gave me enough time and extra points to stave off the cure. I finally succeeded after trying that with the cure at 87% complete

    • profile image

      Anon 

      5 months ago

      Tried it the updated way....still didn’t even kill half the population of earth before the cure was at 100%

    • profile image

      Tim 

      5 months ago

      Update-more depth.. this guide works just beat it.

      Once you have reached step 18 and have put all points toward Total Organ Failure you start getting points rapidly because of deaths but however the cure would rapidly increase.

      Don’t be alarmed , once you have reach enough DNA points ,put points on genetic reshuffle 1 and wait for points to build up and then finally genetic reshuffle 2. Like the guide said..also in my game after I have gotten genetic resuffle 2 I had build more DNA points for another symptom. Choose what ever you like.

      At the end of the game, I followed this guide throughout everyone died but cure was went to a shockling nail biter of 85%. Close call I say.

      *important devolve all symptoms that had evolve without costing any DNA points*and then when you reach step 18, put points insomnia till you reach total organ failure*

      note: images above... also I would like the give a thank you for this written guide even though most of this comment is repeating what the author has written.

    • profile image

      Tim 

      5 months ago

      Guide works, you don’t know the fundamentals of this game.

      Stop cheating and play the game normally,

      Whenever their is a symptom that had evolved with no DNA points, refund it. So their is cure research.

    • profile image

      Reasonable Anonymous 

      6 months ago

      I was about to say this tutorial didn't work, and tried to kill as many people as I could before the cure cured me

      Then I remembered evolving symptoms decreses research progress

      And I won

    • profile image

      Anonymous 

      6 months ago

      It was working really well until people (particularly those in Greenland) just started dying too fast. Somehow those Greenlanders are still going to carry on the world. I'm guessing I should wait until everybody is infected even if I have way more than 100 DNA points.

    • profile image

      SilverBluggoe 

      7 months ago

      I have done this many times and it still hasn't worked. The cure is too fast and the deaths are too slow. This tutorial just doesn't work anymore. I'm gonna try one last time though.

    • profile image

      iscariott93727 

      7 months ago

      bro this is a nice tutorial and I appreciate the work you put into it and stuff but it didn’t work for me. I did everything and it was working out pretty well, but then I built my points to 100 that last time (since you said we could either build our points or wait for everyone to be infected) anyways I jumped the gun and started evolving symptoms since the cure was already at 25 percent. turns out Greenland was untouched and I got yeeted upon

    • profile image

      Telksy 

      7 months ago

      The written tutorial didnt really work, cure was too quick. Tried some modifications like devolving symptoms until everyone was infected to prevent detection, worked better but still failed. Ultimately the video tutorial worked better and I was able to beat it. I did have to push Neural Atrophy to 3 to stop cure progress though.

    • profile image

      The Unknown 

      7 months ago

      Ya know the only tutorials that worked for me is the FREAKIN' BACTERIA AND VIRUS. The others didn't work on me. Like the prion, i have NO DNA when I got Organ failure. It wasn't enough. I'd rate this 4/10 cuz it still helped tho.

      (No Offense)

    • profile image

      mikeyco 

      7 months ago

      961 days and cure at 70%.

      followed tutorial until end where I made slight change.

      Once Greenland is infected start making plague more infectious but not lethal. Also slow cure by increasing drug resistance etc...

      Once 100% of population is infected started adding lethal symptoms and devolve transmission, heat and cold.

    • profile image

      aff 

      7 months ago

      no such thing as dna or not

    • profile image

      bs 

      8 months ago

      cure was at 95% when it stopped moving almost lost

    • profile image

      Jack Jacoby 

      8 months ago

      You would want to spend your DNA at Genetic Reshuffle no matter what at the end (at least to GR2). There'll be a time when you think, "goddammit I'll not make it on time" but you will.

      Deaths will not give you DNA points at first but later it does. I was successful at reaching genetic reshuffle 3 by DEVOLVING ALL OF TRANSMISSIONS and ABILITIES (aside from genetic hardening and genetic reshuffle).

    • profile image

      Cuuliu 

      8 months ago

      This time it worked with a few changes.

      Researched Genetic Hardening 2 directly after 1.

      Waited until everyone was infected - developed symptoms to total organ failure.

      Cure research was on my tail so I deleted the tranmissions and resistances to research genetic reshuffle 1. This gave me enough time to gather points for reshuffle 2 and hold the cure back.

    • profile image

      Cuuliu 

      8 months ago

      Started developing symptoms as soon as Greenland (last country) was infected.

      ~100 infected in Greenland and they started executing the sick and beat and no way to reinfect them with closed seaports..

    • profile image

      Devildaily 

      10 months ago

      The CURE IS Fast

      The Deaths Is SLOW

      The DNA Dont Generate

    • profile image

      11fastgamer 

      11 months ago

      It works, but dont forget generic reshufel and confuse...

    • profile image

      Anonymous 

      11 months ago

      Fifth playthrough using this tutorial, followed everything, keeps getting eradicated.

    • profile image

      Obsessed Vampyre 

      11 months ago

      Name: Blood Plague

      DNA Sequence: Complex

      Difficulty: Casual

      Disease Type: Prion

      Time: 877 days

      Cure Progress: 47% complete

      Score Total: 3790 (2/5 Bio Hazards)

    • profile image

      Sam Bach 

      11 months ago

      It didnt work

    • profile image

      some dude 

      11 months ago

      Now i just have to wait 2 days for it to get to 1000 because of genetic hardening.

    • profile image

      felipaoberm 

      11 months ago

      1119 days but I had devolved all transmission and fight the cure (got to 92%) with neural atrophy 1,2 and 3 and genetic reshuffle 2

    • profile image

      Willy Cuz 

      11 months ago

      The Neural Atrophy Help stop the cure by making it hard to think. Thats how I stopped it at 80

    • profile image

      Garbear 

      12 months ago

      It didn’t work rip off

    • profile image

      nobody 

      12 months ago

      I tried this and the cure finished at 200 million people.

    • profile image

      ShoKWaiV87 

      12 months ago

      Does this work on brutal? I'm trying to complete all of them on brutal (I've completed all on normal already) and want to get the cheats (I have premium). Does it work?

    • profile image

      Dasupercoolboss 

      12 months ago

      The cure completed at 500 000 000 dead people

    • profile image

      snipercat8814 

      12 months ago

      I had about 30,000 healthy left and the plague killed all of its hosts after I followed all of the instructions I think I should try again and as usual add Total Organ Failure once everyone is infected

    • profile image

      ANON 

      13 months ago

      these do take a lot of work and i appreciate your effort. Yet most do not work for me, even as i try them again and again.

      The cure either gets developed too quickly or i run out of DNA to actually do anything about it since i spent so much on the contamination options.

    • profile image

      CJ 

      14 months ago

      After my second attempt it worked. I used someone else’s tips too and I quickly killed a lot of people

    • profile image

      guest 

      14 months ago

      Sorry, this doesn't work anymore even updated

    • profile image

      Antonella 

      15 months ago

      Yes, I'm the same person that wrote yesterday. I followed your instructions again and again and, after 4 times I finally made it. Everyone was dead and research stopped at 90%.

      I guess that the game's IA may be more complex and also adapt to what the player does.

      I've followed all your walkthroughs to the T and some may take a few times to work but they do. Also I'd like to thank you for all your hard work.

      Going to nano now! Bye!

    • profile image

      Antonella 

      15 months ago

      I followed your instructions and when the cure was complete Greenland was still 100% healthy.

    • profile image

      N/A 

      15 months ago

      This doesn’t work

    • profile image

      N/A 

      16 months ago

      Don't get genetic hardening.

    • profile image

      n/a 

      16 months ago

      Worked great! Won at 78%. Thanks for the help!

    • profile image

      nope 

      16 months ago

      followed these instructions perfectly and the cure beat me. it went down when i added more symptoms but by then the disease was killing people faster than it infected them. also the mutated symptoms alerted people who closed borders which generally made it harder, and iceland had a low infection rate so they executed the infected and closed their borders which meant i couldn't win. it is not due to people not following these steps, it is down to many variables that cannot be foreseen in individual gameplay. this tutorial will work for some and not for others, unfortunately i was not one of the lucky ones.

    • profile image

      Duey 

      17 months ago

      Thanks for your hard work. I must be missing something. I can't seem to win. The cure is always reached so quickly once I get to total organ failure. People just aren't dying very fast. I'll give it another go

    • profile image

      N/A 

      17 months ago

      The cure got to 98%. Just barely won.

    • profile image

      Mackenzy 

      17 months ago

      For people saying it didn't work and that you followed it to a T obviously you didn't. She has worked hard on these tutorials and doesn't deserve the bullshit i see in the comments. If you followed her steps to the letter, then it should work. I have used her tutorials for the past hour and have gotten all the way up to this disease with her help and i kept dying for days stuck at the Bacteria level. So obviously you didn't follow instructions therefore it isnt her fault

    • profile image

      Fabian 

      18 months ago

      Doesn’t work I’ve done it 6 times and I always get eradicated before they all die.

    • profile image

      Ganegirl 

      18 months ago

      Doesnt work for me.. i tried it two times still canmt beat it

    • profile image

      William 

      19 months ago

      for those who lose, I beat it at 99% left to cure it, after you use Genetic reshuffles, make sure to devolve transmissions and abilities and put towards symptoms like Coma and Insanity (To the left) that slows down progress, then just pray that the leading nation of the cure dies out. Hope this helps

    • profile image

      Michael 

      20 months ago

      You tutorials work like like.... idk but they’d work

      All of them thank you!

    • profile image

      Marcus 

      20 months ago

      this worked thank you

    • profile image

      Joe 

      20 months ago

      I followed to a T and was defeated twice at the last minute. The most DNA points I can get after step 16 is 71 and then it outright stops. Devolved all symptoms and abilities to fight the cure, which takes less than a minute to reach 100%. Ive lost to this level a total of 9 times now. :(

    • profile image

      Geoff 

      20 months ago

      On the normal prion I found that I had to devolve symptoms to escape detection. I reached 98% world infection before new disease was receiving attention. Once I got 100% your advice of ramping up symptoms to kill and genetic reshuffling worked like a charm.

    • profile image

      Gravy 

      21 months ago

      Barely worked, however did in the end! I had to take some extra action to defend against the cure though, like devolving certain transmissions and abilities, and evolving the Prion's special ability at the beginning, along with adding extra lethal symptoms, but it worked!

    • profile image

      Justice Marie 

      21 months ago

      I love your tutorials!! They have all worked for me. I hope you make more for the other stuff in the game.

    • profile image

      SarahMariePardy 

      21 months ago

      This doesn't work. I tried it about 5 times before going to a new walkthrough that told me to devolve symptoms as they come and focus on transmission + cold res, where as yours says to allow symptoms. Once everyone was infected the cure hadn't even started. So then I evolved symptoms to total organ failure and as more points came in (plus I devolved transmissions for more points since everyone was ill already) I used them to fight the cure. Once the symptoms start, the cure starts and it's very fast. I was BARELY able to complete it this way, but did. 93% cure when I finished.

    • profile image

      Vicki 

      21 months ago

      Even with your update this still doesn't work. I eradicated 97% of the world but the cure saved the last 3%. Would love to know if anyone has completed this one or if they've broken it with the recent tweaks? I just want to move on...

    • profile image

      Matt 

      22 months ago

      Yep this one does NOT work

    • profile image

      Wow 

      23 months ago

      First guide that I've looked at that actually hasn't worked at all.

      Following it to the letter results in less than a quarter of the total population dead and 100% cured.

      Not allowing symptoms to mutate results in half the amount of people dead but still 100% cured.

      Doesn't really work if you follow this guide at all.

    • profile image

      Jake 

      23 months ago

      I had everyone infected and once I activated total organ failure the cure caught up really fast and people weren't dying fast at all

    • profile image

      Louis 

      23 months ago

      No Help... Still lost

    • profile image

      Rich 

      24 months ago

      This was THE most useless guide I've ever tried. No help, I was doing better on my own.

    • profile image

      Redcloud 

      24 months ago

      This doesn't work at all by the time everyone is infected I barely enough dna points for total organ failure and sometimes not enough so no gen resuffle 1,2 which allows the cure to reach 100%

    • profile image

      Shelby 

      2 years ago

      By the end, you have no DNA points to spend. Production slows down. You can't buy Organ Faliure, let alone Genetic Reshuffle...

    • profile image

      Doogo moog 

      2 years ago

      you said air resistance

    • profile image

      Wow 

      2 years ago

      Finished with 98% cure

    • profile image

      DragonSkitters 

      2 years ago

      Air Resistance?

    • profile image

      Fox Gaming 

      2 years ago

      @Stuqid Water Resistance is for Boats becoming immune to your virus (As the game describes it, getting new air filters) and Air Resistance is the same, but for Airplanes. The Resistances are for two things (That I've noticed.) 1. Allowing Boats and Airplanes to become infected again after getting new air filters, and 2. Increasing chance of Airplanes and Boats to become infected.

    • profile image

      orteam 

      2 years ago

      Thanks :)

    • profile image

      deatheye 

      2 years ago

      advice use the first dna gene u get and when everyone is infected and dying and the cure is close to be done devolve the weak stuff

    • profile image

      Revampedharpy09 

      2 years ago

      just going to give some advice here guys, i tried this as written, and even with genetic reshuffle 1, 2 and 3 it didnt work, so i tried again, this time ignoring the "allow symptoms to mutate" and devolved them just like with bacteria and it has worked. aside from that change, i used the tutorial as written.

      That said, ive only tried it once, so whether or not this is a reliable method, i cant say.

    • profile image

      Stuqid 

      2 years ago

      What is Water and Air Resistance?

    • profile image

      Clark Kim 

      2 years ago

      Just finished. 1st thing is 1st. You need to follow the stratagy exactly till step 16. (Except, one, you might want to try livestock, instead of blood. Two, step 14 wouldn't be necessary for you to spread infection further in hot climate regions. Three, do not allow any symptoms during the infection.)

      Now, here are several essential points.

      1. Confirm the every single one in the world is infected.

      2. Start retrieving DNA points from Abilities (Heat/Cold resistance) and Transmission (Air/Water/Livestock)

      3. Begin developing symptoms till total organ failure first!

      (Also, at this point, you can now allow the symptoms to be developed)

      4. Concentrate on investing DNA points in Abilities (Drug resistance/Genetic Hardening/Genetic Reshuffle, these 3 factors have to be maxed out!)

      5. If possible, coma also would be greatly helpful to prevent reaching cure 100%.

      At the end, the result were the cure development 83% and wipe out in 1506 days.

      Wish you luck!!

    • profile image

      Cara 

      2 years ago

      I have tried this about 10 times and it always gets cured before everybody dies off. I got really close but the cure beat me. What DNA can we use? Which ones would be the best to make sure I am able to beat this level?

    • profile image

      someone 

      2 years ago

      this one did not help me the other ones helped but not this one i followed everything and i did not work ......help plz

    • Fox Gaming profile image

      Fox Gaming 

      2 years ago

      Great Guide, but what if it evolves a deadly symptom while i'm still trying to infect?

    • profile image

      Anonymous 

      2 years ago

      I followed this walkthrough EXACTLY as written. I've used several other of these and they worked very well. This one just completely allowed the cure to be completed and didn't stop it. I lost with only half a billion people dead and the cure just stopped the disease in its tracks and easily caused me to lose. Please add something for cure prevention!!!!

    • profile image

      Wow! 

      2 years ago

      Wait a minute! I used this tutorial on parasite and it worked fine! Guess I've got Prion sorted out now!

    • profile image

      Wow! 

      2 years ago

      I finished in 597 days and the cure was only at 43%

      It is common sense after total organ failure. Just keep saving up for genetic reshuffles. And evolve deadly symptoms (increase the amount of daily deaths).

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