How to Beat Plague Inc. Prion on Normal

Updated on March 6, 2016

Beating Prion on Normal

This tutorial, while similar to the Virus tutorial I posted, is a little different in the way you go about the game. Please make sure you read the steps carefully and follow them to a T. If you have come this far, you probably know the game pretty well now. Let's get this started!

First things first: you are allowing symptoms to mutate.

  1. Start your virus in South Africa.
  2. Build DNA points to 50.
  3. Get Air Resistance 1.
  4. Get Air Resistance 2.
  5. Get Water Resistance 1.
  6. Get Blood 1.
  7. Build DNA Points to 50.
  8. Get Water Resistance 2.
  9. Get Drug Resistance 1.
  10. Get Heat Resistance 1.
  11. Get Cold Resistance 1.
  12. Build DNA Points to 100.
  13. Get Drug Resistance 2.
  14. Get Heat Resistance 2.
  15. Get Cold Resistance 2.
  16. Get Genetic Hardening 1.
  17. Build your points to 100 or until everyone is infected.
  18. Once you have either reached 100 points or everyone is infected, put points into symptoms leading to Total Organ Failure. Spend your remaining points into anything else that is lethal. Don't worry about the cure. However, if you want you can spend any additional points to slow the cure for a higher score.

Update to Tutorial

I have noticed there being a change in the current tutorial as it stands.

All you have to do is put your additional points into genetic reshuffle 1 and genetic reshuffle 2 to prevent the cure from going 100%

Video: Prion on Normal Walkthrough

Updated: My stats as of 3/27/2014.
Updated: My stats as of 3/27/2014.

About the Author

Ashleign is my alias and a character I play on the internet. I have used this nickname for several years. I have worked in IT for about four years. Before that, I worked as an EMT in EMS. There, I drove the ambulance mostly, but I can say that I was in the room while a life was actually being saved—that was a cool thing to see. Bless our troops, fire, police, and EMS workers they have an incredibly hard job, and I love them with every bit of my heart. Especially the police.

I've been working very hard on these tutorials for you and appreciate any and all feedback you want to provide. Please let me know how you did, I would love to hear from you!

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Questions & Answers


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      • profile image

        Ryan 32 hours ago

        doesnt work it cant kill people that quick ive tried

      • profile image

        ANON 10 days ago

        these do take a lot of work and i appreciate your effort. Yet most do not work for me, even as i try them again and again.

        The cure either gets developed too quickly or i run out of DNA to actually do anything about it since i spent so much on the contamination options.

      • profile image

        CJ 6 weeks ago

        After my second attempt it worked. I used someone else’s tips too and I quickly killed a lot of people

      • profile image

        guest 7 weeks ago

        Sorry, this doesn't work anymore even updated

      • profile image

        Antonella 8 weeks ago

        Yes, I'm the same person that wrote yesterday. I followed your instructions again and again and, after 4 times I finally made it. Everyone was dead and research stopped at 90%.

        I guess that the game's IA may be more complex and also adapt to what the player does.

        I've followed all your walkthroughs to the T and some may take a few times to work but they do. Also I'd like to thank you for all your hard work.

        Going to nano now! Bye!

      • profile image

        Antonella 8 weeks ago

        I followed your instructions and when the cure was complete Greenland was still 100% healthy.

      • profile image

        N/A 2 months ago

        This doesn’t work

      • profile image

        N/A 2 months ago

        Don't get genetic hardening.

      • profile image

        n/a 3 months ago

        Worked great! Won at 78%. Thanks for the help!

      • profile image

        nope 3 months ago

        followed these instructions perfectly and the cure beat me. it went down when i added more symptoms but by then the disease was killing people faster than it infected them. also the mutated symptoms alerted people who closed borders which generally made it harder, and iceland had a low infection rate so they executed the infected and closed their borders which meant i couldn't win. it is not due to people not following these steps, it is down to many variables that cannot be foreseen in individual gameplay. this tutorial will work for some and not for others, unfortunately i was not one of the lucky ones.

      • profile image

        Duey 3 months ago

        Thanks for your hard work. I must be missing something. I can't seem to win. The cure is always reached so quickly once I get to total organ failure. People just aren't dying very fast. I'll give it another go

      • profile image

        N/A 3 months ago

        The cure got to 98%. Just barely won.

      • profile image

        Mackenzy 4 months ago

        For people saying it didn't work and that you followed it to a T obviously you didn't. She has worked hard on these tutorials and doesn't deserve the bullshit i see in the comments. If you followed her steps to the letter, then it should work. I have used her tutorials for the past hour and have gotten all the way up to this disease with her help and i kept dying for days stuck at the Bacteria level. So obviously you didn't follow instructions therefore it isnt her fault

      • profile image

        Fabian 5 months ago

        Doesn’t work I’ve done it 6 times and I always get eradicated before they all die.

      • profile image

        Ganegirl 5 months ago

        Doesnt work for me.. i tried it two times still canmt beat it

      • profile image

        William 6 months ago

        for those who lose, I beat it at 99% left to cure it, after you use Genetic reshuffles, make sure to devolve transmissions and abilities and put towards symptoms like Coma and Insanity (To the left) that slows down progress, then just pray that the leading nation of the cure dies out. Hope this helps

      • profile image

        Michael 6 months ago

        You tutorials work like like.... idk but they’d work

        All of them thank you!

      • profile image

        Marcus 6 months ago

        this worked thank you

      • profile image

        Joe 7 months ago

        I followed to a T and was defeated twice at the last minute. The most DNA points I can get after step 16 is 71 and then it outright stops. Devolved all symptoms and abilities to fight the cure, which takes less than a minute to reach 100%. Ive lost to this level a total of 9 times now. :(

      • profile image

        Geoff 7 months ago

        On the normal prion I found that I had to devolve symptoms to escape detection. I reached 98% world infection before new disease was receiving attention. Once I got 100% your advice of ramping up symptoms to kill and genetic reshuffling worked like a charm.

      • profile image

        Gravy 8 months ago

        Barely worked, however did in the end! I had to take some extra action to defend against the cure though, like devolving certain transmissions and abilities, and evolving the Prion's special ability at the beginning, along with adding extra lethal symptoms, but it worked!

      • profile image

        Justice Marie 8 months ago

        I love your tutorials!! They have all worked for me. I hope you make more for the other stuff in the game.

      • profile image

        SarahMariePardy 8 months ago

        This doesn't work. I tried it about 5 times before going to a new walkthrough that told me to devolve symptoms as they come and focus on transmission + cold res, where as yours says to allow symptoms. Once everyone was infected the cure hadn't even started. So then I evolved symptoms to total organ failure and as more points came in (plus I devolved transmissions for more points since everyone was ill already) I used them to fight the cure. Once the symptoms start, the cure starts and it's very fast. I was BARELY able to complete it this way, but did. 93% cure when I finished.

      • profile image

        Vicki 8 months ago

        Even with your update this still doesn't work. I eradicated 97% of the world but the cure saved the last 3%. Would love to know if anyone has completed this one or if they've broken it with the recent tweaks? I just want to move on...

      • profile image

        Matt 9 months ago

        Yep this one does NOT work

      • profile image

        Wow 9 months ago

        First guide that I've looked at that actually hasn't worked at all.

        Following it to the letter results in less than a quarter of the total population dead and 100% cured.

        Not allowing symptoms to mutate results in half the amount of people dead but still 100% cured.

        Doesn't really work if you follow this guide at all.

      • profile image

        Jake 10 months ago

        I had everyone infected and once I activated total organ failure the cure caught up really fast and people weren't dying fast at all

      • profile image

        Louis 10 months ago

        No Help... Still lost

      • profile image

        Rich 10 months ago

        This was THE most useless guide I've ever tried. No help, I was doing better on my own.

      • profile image

        Redcloud 10 months ago

        This doesn't work at all by the time everyone is infected I barely enough dna points for total organ failure and sometimes not enough so no gen resuffle 1,2 which allows the cure to reach 100%

      • profile image

        Shelby 11 months ago

        By the end, you have no DNA points to spend. Production slows down. You can't buy Organ Faliure, let alone Genetic Reshuffle...

      • profile image

        Doogo moog 11 months ago

        you said air resistance

      • profile image

        Wow 12 months ago

        Finished with 98% cure

      • profile image

        DragonSkitters 12 months ago

        Air Resistance?

      • profile image

        Fox Gaming 12 months ago

        @Stuqid Water Resistance is for Boats becoming immune to your virus (As the game describes it, getting new air filters) and Air Resistance is the same, but for Airplanes. The Resistances are for two things (That I've noticed.) 1. Allowing Boats and Airplanes to become infected again after getting new air filters, and 2. Increasing chance of Airplanes and Boats to become infected.

      • profile image

        orteam 12 months ago

        Thanks :)

      • profile image

        deatheye 12 months ago

        advice use the first dna gene u get and when everyone is infected and dying and the cure is close to be done devolve the weak stuff

      • profile image

        Revampedharpy09 13 months ago

        just going to give some advice here guys, i tried this as written, and even with genetic reshuffle 1, 2 and 3 it didnt work, so i tried again, this time ignoring the "allow symptoms to mutate" and devolved them just like with bacteria and it has worked. aside from that change, i used the tutorial as written.

        That said, ive only tried it once, so whether or not this is a reliable method, i cant say.

      • profile image

        Stuqid 15 months ago

        What is Water and Air Resistance?

      • profile image

        Clark Kim 16 months ago

        Just finished. 1st thing is 1st. You need to follow the stratagy exactly till step 16. (Except, one, you might want to try livestock, instead of blood. Two, step 14 wouldn't be necessary for you to spread infection further in hot climate regions. Three, do not allow any symptoms during the infection.)

        Now, here are several essential points.

        1. Confirm the every single one in the world is infected.

        2. Start retrieving DNA points from Abilities (Heat/Cold resistance) and Transmission (Air/Water/Livestock)

        3. Begin developing symptoms till total organ failure first!

        (Also, at this point, you can now allow the symptoms to be developed)

        4. Concentrate on investing DNA points in Abilities (Drug resistance/Genetic Hardening/Genetic Reshuffle, these 3 factors have to be maxed out!)

        5. If possible, coma also would be greatly helpful to prevent reaching cure 100%.

        At the end, the result were the cure development 83% and wipe out in 1506 days.

        Wish you luck!!

      • profile image

        Cara 16 months ago

        I have tried this about 10 times and it always gets cured before everybody dies off. I got really close but the cure beat me. What DNA can we use? Which ones would be the best to make sure I am able to beat this level?

      • profile image

        someone 16 months ago

        this one did not help me the other ones helped but not this one i followed everything and i did not work plz

      • Fox Gaming profile image

        Fox Gaming 16 months ago

        Great Guide, but what if it evolves a deadly symptom while i'm still trying to infect?

      • profile image

        Anonymous 17 months ago

        I followed this walkthrough EXACTLY as written. I've used several other of these and they worked very well. This one just completely allowed the cure to be completed and didn't stop it. I lost with only half a billion people dead and the cure just stopped the disease in its tracks and easily caused me to lose. Please add something for cure prevention!!!!

      • profile image

        Wow! 17 months ago

        Wait a minute! I used this tutorial on parasite and it worked fine! Guess I've got Prion sorted out now!

      • profile image

        Wow! 17 months ago

        I finished in 597 days and the cure was only at 43%

        It is common sense after total organ failure. Just keep saving up for genetic reshuffles. And evolve deadly symptoms (increase the amount of daily deaths).

      • profile image

        Annonymous 17 months ago

        When the humans started to "cure" my disease (Raggmunk) I got the Neural atrophy 1 and 2 plus Genetic hardening 2 just to slow the cure down which (probably) saved me. ended up winning with the cure at 73% (in addition to these abillities, I used 2 reshuffles) Hopefully you can test this and find it useful (at least to some extent)

      • Jen Anderson profile image

        Jen Anderson 17 months ago

        I followed this a few times but had no success, so I followed the same plan I did for bacteria and just managed to squeak by with completion at 1381 days and the cure at 94%. I devolved all mutations until there were no healthy people left and then dumped points into symptoms to get to TOF. Then I used any remaining points on genetic reshuffles and hardening. Thanks for the pointers though

      • profile image

        Didnt work 17 months ago

        Didn't work!!!!!

      • profile image

        Sam 19 months ago

        It never worked for me even i followed the rules☹️

      • Ashleign profile image

        Ashleign 19 months ago

        Well, I try to approve the comments of people trying to help with alternative solutions. I am glad that DMisteri was able to help you. Special thanks for DMisteri!

      • profile image

        Eljay77 19 months ago

        Didn't work for me solely using Ashleighns (First time Ash's stuff hasn't worked) but with a bit of help from DMisteri post I FINALLY got there! Simply need a bit of patience and a little more hard work.

        Thanks guys

      • profile image

        Berke 20 months ago

        Needed last minute medical upgrades

      • Ashleign profile image

        Ashleign 20 months ago

        They aren't following the directions and blame me for them skipping ahead.. It happens. I know the tutorials work.

      • profile image

        Yo 20 months ago

        I don't know how this doesn't work for some. I followed all your steps for everyone and ow I beat the game lol so either way your tips are amazing and thank you

      • profile image

        Berta 20 months ago

        Feel bad for cheating a tad... but i cant help it without u an ur amasing tips id still b stuck on bacteria getting my ass kicked by the cure!! Lots of love xxx

      • profile image

        ed 21 months ago

        I beat the game at 78% cure. I only evolved up to : Air 2, Water 2, Heat Resistance 2, and Cold Resistance 2. Then I evolved ONLY cough and sneezing just to infect everyone. The disease was noticed but the cure progress slowly.

        I waited and collected DNA points up to 150 then I evolved symptoms up to TOF, Coma, and Paralysis.

        Then you must evolve up to Neural Atrophy 3. Trust me, this slows down the cure progress as it affects the brain of the researchers.

        Lastly I work my way up to evolving Genetic Reshuffle 2.

        Game is finished and a success.

      • profile image

        Shinobigarth 21 months ago

        works, but you HAVE to devolve all transmission stuff (including the abilities that deal with infectivity) once everyone is sick, and stay on top of the cure at the end, getting Genetic Reshuffles as soon as you can. basically at the end put everything into Reshuffles, TOF, Coma, Paralysis and i did Seizures also. devolve everything else including the symptoms used to get to TOF, Coma, etc to give you more points for the Reshuffles.

        worth noting i also had the one gene mod that gives you 4 points for a devolve, and i just barely made it, so i almost feel like that mod is pretty necessary.

      • profile image

        Janie 21 months ago

        i've followed this five times now and it doesn't work

      • profile image

        Janie 21 months ago

        never worked, the cure got to 100%

      • profile image

        mucholoco 21 months ago

        Hi! Did you mean Air Transmission for (3-4) and Water Transmission for (5,8)?

      • profile image

        LeeLee 22 months ago

        once all was infected, I devolved all transmissions, heat, cold, and rash. Evolved genetic shuffle and this triggered enough points to keep coming in so I increased legality/harder to cure symptoms and it work with 96% to cure

      • profile image

        Jo 22 months ago

        This also works for parasite. Whoops.

      • Ashleign profile image

        Ashleign 22 months ago

        Oddly enough I am working on a Brutal Santa's little helper..

      • profile image

        aftrprzn 22 months ago

        I've beaten all the regular scenarios on easy, normal, and brutal; I can't beat any of them on mega-brutal.

        Also, I can't beat "Santa's Little Helper" on brutal.

        Would love some help on these, please.

        Thanks in advance.

      • profile image

        firox 22 months ago

        put tutorials about senerios

      • profile image

        JonDon 23 months ago

        @chuck - as someone who has followed every detail to a T and still failed, I feel compelled to say that in a game like Plague which is so full of and so dependent upon variables and endless permutations, it doesn't really matter what strategy you follow or how closely you adhere to it - there will always be the possibility of undesirable outcomes. Just like in real life. This is certainly not a knock on the author's strategies. I am very grateful for his input and help as well as those here who also have offered their variations and walkthrus in the comments.

        Thanks to everyone.

      • profile image

        harms 23 months ago

        at the end it completely stopped giving me DNA points so I couldn't fight the cure

      • profile image

        chuck 23 months ago

        Ive used all your tutorials thusfar and i have to say they work A+ 100%. Users complaining of defeat must not be following the tutorial to a T like you suggest...... Thanks for your hard work!

      • profile image

        DMisteri 23 months ago

        First and foremost Devolve all Symptoms

        Follow the first 11 steps in the tutorial except when you get to step 6 use Livestock 1 not blood 1 since the biggest disaster that came from Prion was Mad Cow Disease.

        Use Cold Resistance 2 to completely infect the world and in the process while you wait build up your points you will need them.

        Once the world is totally infected start adding Symptoms starting with Insomnia and working your way up the middle to Organ Failure. Add remaining points to Bird 1.

        The Cure will rise however as your points build add them to Genetic Reshuffle 1,2,and 3 by this time the Cure will stop and the world will be 90% dead. I hope this help and have fun wiping out the world you sick individuals

      • profile image

        Tony Stank 23 months ago

        I DID IT


        I used the guide, and that didnt work AT ALL

        So, I did it this way

        Drug Resist 1 and 2, Genetic Hardening 1 and 2

        Devolved all mutations as they came

        Air 1 and 2, Water 1 and 2, Extreme Bioaresol

        Birds 1 and 2, rats 1

        Cold 1 and 2, heat 1

        Neural Atrophy 1 and 2

        As soon as everyone was infected, and I was at about 107 DNA points, I went in and put in Coughing, Sneezing, Immune Suppression, and Total Organ Failure.

        I devolved all my transmissions and the heat and cold.

        I ramped up my Genetic Reshuffle 1-3

        Cure is still 79%

        And the world is dyiiiiinnnngggggg!


      • profile image

        noirp 2 years ago

        it work! while there's so many cures i was like don't care about the cures

      • Ashleign profile image

        Ashleign 2 years ago

        The video and the tutorial are accurate. Don't get ahead of the tutorial it's designed to take long.

      • profile image

        theanubisdragon 2 years ago

        did every thing in video defeat in under 2 mins wtf

      • profile image

        Wesbest 2 years ago

        I had everyone infected with no symptoms,and then built up to total organ failure,but the cure was made crazy fast. How do I slow to cure.?

      • profile image

        Andrei 2 years ago

        I killed all the people finishing with 0 DNA points and 99% of cure. :)

      • profile image

        Jessica 2 years ago

        Followed this exactly. I found that the cure was quickening which seemed to be a common issue and I didn't have enough for Genetic Reshuffle 2 so then I devolved my Heat, Cold, Blood, Air, Water and received 2 DNA points for each that helped me with the Reshuffle. The DNA points automatically rose and within seconds I had enough points to keep assigning symptoms and then eventually the cure stopped at 83%.

        THANK YOU :D

        I was stuck on this one for a longgggggg time.

      • profile image

        nikolas 2 years ago

        it did not work, i followed the tutorial step by step, there is 500k people left in the world and they invent the cure at an astonishing rate

      • profile image

        Lizzy 2 years ago

        This didn't work for me. I read the comments before starting my first playthrough of prion, and seeing as how so many people found that this tutorial didn't work out for them, I opted to devolve any symptom mutations until all of my countries were infected, so that I would have a head start once it got noticed. Aside from that, I followed the tutorial "to the T" and even though everyone was infected by the time I evolved total organ failure, the cure still beat me before I managed to kill off more than almost 1/3 of the world population.

        I love your tutorials and this is the only one that hasn't worked for me thus far. Perhaps you should revamp it entirely seeing as how so many people found that it did not work for them? Regardless thank you for your helpful posts!

      • profile image

        Tanner 2 years ago

        this worked on normal, but not brutal

      • Ashleign profile image

        Ashleign 2 years ago

        I'll re-work it and see what I come up with thanks for the feedback

      • profile image

        PlagueRat 2 years ago

        Followed this tutorial to the "T" 5 times in a row, each time the result was the same.. Cure happens before 50% eradication of population.

      • profile image

        Plague inc. Evolved 2 years ago

        It works

      • profile image

        Undyne 2 years ago

        Work! i get DNA points Faster!

      • profile image

        Rozack 2 years ago

        1.Start in Saudi Arabia

        2.Don't let Lethality Way Up!

        3.follow Asgleign

        4.have fun!

      • profile image

        Lol 2 years ago

        Worked like a charm, thanks!

      • Ashleign profile image

        Ashleign 2 years ago

        Wow, haven't had this kind of comment for a while. I remember following up on this tutorial just the other day and it worked perfectly. Did you follow the tutorial exactly?

      • profile image

        Maddy 2 years ago

        100% cure before even Canada got completely infected! Didn't work

      • profile image

        Dararith 2 years ago

        Following this exactly literally only allowed me to kill about 500 million people, maximum. Otherwise, cure would be able to surface before then.

      • profile image

        Staci 2 years ago

        Dude i ended up eradicating myself because greenland didn't infect faster than they died.... I'm pissed...

      • profile image

        A=Unknown 2 years ago

        Treat the disease as a Bacteria not as a virus. It will help. Or Simply don't let the symptons mutate.No need to go to Heat Resistance 2, keep it at 1,but get the cold resistance at 2. Use Rodents instead of Blood.

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        42ndsheep 2 years ago

        i had to change this to make it work, but good baseline i guess (I won with 96% cure and no more genetic reshuffles, immensely close game, the cure had actually gotten to 99% when i was able to reshuffle lol)

      • profile image

        Pinkie Pie 2 years ago

        Add loved it.

        Won on my 1st try.

      • profile image

        Terry 2 years ago

        I had almost all symptoms and the cure hadn't even started but it still caught up in the end. This is a bad tutorial.

      • profile image

        Karl 2 years ago

        Start in egypt- 2 port 1 airport

        Get heat resistance 1, then drug reaistance 1 (egypt will spread to saudi,, US, and Spain/UK) then get cold resistance. At the same time get water and air transmission only. Dont use any others since its detectable. Devolved any symptom mutated. Do not let any sympton exist until all people are infected. Depending on ur game, change the peiority slightly whether to increase the defend(ability) or straight kill (symptoms) but make sure if u ever choose to expose ur desease, make sure u have enough point to go straight to organ failure. Thats how i played. Took me 2020 but it was easy.

      • profile image

        Green 2 years ago

        It took me 2 times to beat it

      • profile image

        UncleKid 2 years ago

        I hope you guys figure it out for yourself. This guide is misguiding. You cant really win with this. I follow it partiolly and add some minor modifications.

        1. Start in India

        2. Dont take Heat res 2 (its useless)

        3. Take Roden instead to speed up EU and US spread

        4. For more fatality I add Internal Haemorrhaging

        5. Use all your spare points to slow cure

        I manage to win it this way. Cure get to 91 but able to slow it down.

        Hope this will help.

        Good luck exterminating humanity :)

      • profile image

        You 2 years ago

        I was followed this to the teeth. But every time it goes to slow. I got every single symptom at once before the cure even started and it still caught up and one

      • profile image

        Zach 2 years ago

        It didn't work for me. I tried it like 10 times. I follow the instructions exactly, but it does not give me DNA points fast enough.

      • profile image

        Savis 3 years ago

        Thanks for your guide! I followed exactly and I finally beat it, but had to use a few tweaks. Even following everything exactly the cure progress got up to 93% before I took further action. After your steps I devolved Water/Air 2, Blood 1, and a few of the symptoms not leading to total organ failure. I also had to end up buying all 3 of the Prior special abilities, this knocked the cure rate back to 83% and gave the disease enough time to finish off the planet.


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