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How to Beat "Plague Inc." Prion on Normal


Ashleign is a woodworker and yard enthusiast. She can be found as enthusiast.mysticalnerdtv on Instagram and mysticalnerd on Twitch.

Follow along with this walkthrough for "Plague Inc."

Follow along with this walkthrough for "Plague Inc."

Beating Prion on Normal

This tutorial, while similar to the Virus tutorial I posted, is a little different in the way you go about beating the game. Please make sure you read the steps carefully and follow them to a T. If you have come this far, you probably know the game pretty well now. Let's get this started!

Step-by-Step Walkthrough

First things first: You are allowing symptoms to mutate.

  1. Start your virus in South Africa.
  2. Build DNA points to 50.
  3. Get Air Resistance 1.
  4. Get Air Resistance 2.
  5. Get Water Resistance 1.
  6. Get Blood 1.
  7. Build DNA Points to 50.
  8. Get Water Resistance 2.
  9. Get Drug Resistance 1.
  10. Get Heat Resistance 1.
  11. Get Cold Resistance 1.
  12. Build DNA Points to 100.
  13. Get Drug Resistance 2.
  14. Get Heat Resistance 2.
  15. Get Cold Resistance 2.
  16. Get Genetic Hardening 1.
  17. Build your points to 100 or until everyone is infected.
  18. Once you have either reached 100 points or everyone is infected, put points into symptoms leading to Total Organ Failure. Spend your remaining points into anything else that is lethal. Don't worry about the cure. However, if you want, you can spend any additional points to slow the cure for a higher score.

Video: Prion on Normal Walkthrough

Updated: My stats as of 3/27/2014.

Updated: My stats as of 3/27/2014.

More "Plague Inc." Tutorials

Gameplay in "Plague Inc."

Gameplay in "Plague Inc."

Please Answer the Poll

Questions & Answers

Question: This didn't work. I ended up with all the hosts being killed but I lost because there were still healthy people. What happened?

Answer: Prion changes is the short story. Sometimes the tutorial works, sometimes it doesn't. Try again see if you have success if not.. Minecraft Mobile is fun.


Worked! on September 08, 2020:

It worked SO well, I did all of your tutorials from fungus and all worked first try.

Unknown on June 25, 2020:

Does not work. Tried more than 5 times

Sally on June 10, 2020:

if you are doing it, here are some tips:

When everyone has been infected, devolve the transmission. You will get DNA which will help fund your murder.

Don't give up.

When buying the upgrades, pause the game and then upgrade.

Thats all I can think of, but I hope it helps!

Chris on May 23, 2020:

Yuo this is BS, I tried 4 times

PJ on May 12, 2020:

Tried once, didn't work. Greenland not infected before cure well under way. Going to try water transmission much earlier.

Marian on April 28, 2020:

You Need to make sure, that the WHOLE Population is enfected before starting to develop deadly Symptoms all at once. Also set the ability for making difficult Tasks hard to lvl. 3, stops them making the Cure as well. I won like that, should work for u too :)

Ava on April 13, 2020:

Didn’t work. My prion got discovered at only 56million infections GLOBALLY. I tried this 3 times and still the exact same result. Cured. Cured. Cured.

Jose king on March 10, 2020:

I clutched this entire 1st round! The cure was literally at 100 then went back to 99 and again to 100 yet i still won!!!!

Deimos Gaming on March 09, 2020:

Thanks it spread very fast faster than parasite

alexboncayao on February 26, 2020:

I already WON after 4th attempt. This is how.

1. DEVOLVE symptons immediately

2. SKIP Blood 1 (to save DNA immediately for shuffle 2)

3. When all are infected, devolve transmission and abilities (except drug) to earn DNA and to complete shuffle and hardening.

expect 85-90% cure progress. I got it at 86% only.

sexualchoco on February 24, 2020:

The video helped me a lot the step by step didn't tho but thanks :)

mike hawk on February 20, 2020:

This is actual trash of a tutorial did it 17 times never worked once and I have genetic reshuffle 3 and it still didn't work

SURVIVOR on February 04, 2020:

This tutorial sort of worked for me. The cure reached 100% about 3 billion deaths in. Got just enough DNA in time for a reshuffle. Cure hit 100% again at 4 billion deaths. Again, just got enough for reshuffle 2. At more or less 5 billion, i AGAIN just got the exact amount for reshuffle 3. After this i had no more reshuffles and DNA, but luckily people were dying so research slowly increased from a couple dozen days to years.

Just remember to devolve all abilities and transmissions after the entire world is infected!

Stu on February 03, 2020:

I tried around 15 times hours and hours of work wasted.

Fabi on February 02, 2020:

Doesn't work 4 me. I have tried this at least 5 times now and every time I try it the cure just catches up to me in seconds.

Erick on January 01, 2020:

I did it. The guide Was very useful, the cure was going very fast but when i also add the Genetic Reshufful 1 2 3 the cure Stopped.

God on December 15, 2019:

Worked perfectly

sunny on November 26, 2019:

i was reading the comments and i wasn’t sure that it was going to work or not but it did and i was so happy!! i completed the level with the cure 83% done. i’d been trying to do this for ages but failed every time so ty for the help!

PrionNonChampion on November 21, 2019:

Awful guide. Have tried a dozen times. Never works.

Ashley on October 30, 2019:

Thanks for the tips.. I changed it up a little but got it done at 90% research the first time :)

person on October 27, 2019:

The cure keeps developing too fast. Apart from that, it's absolutely excellent.

ur mom on October 17, 2019:

holy crap it worked and the cure reached 95%

Maya on October 14, 2019:

It worked but it was a really closed game. 77% cure

Jade on October 05, 2019:

I think the major wrinkle in this for me wasn’t allowing the mutations to occur. This caused cure research to start far too early. You definitely want to devolve all mutations until everyone is infected. If you do that, and out all extra points into genetic reshuffling, the plan works like a charm.

aaa on July 24, 2019:

thanks it worked in one try

nikoskoub on July 17, 2019:

Doesn't work

CoCoGamer on June 26, 2019:

What do you mean by "air/water resistance"? Do you mean transmition?

Ashleign (author) on June 11, 2019:

it happens.

Panda on June 06, 2019:

Instruction not clear, ended up making earth flat

Flerovium on May 20, 2019:

I Melted In this prion achoochooness because theyre like killing me like 2016

Ashleign (author) on May 17, 2019:

Way to go!

Adriana on May 17, 2019:

Finally beat it after 4 tries although I did a few things differently...

- Get the gene that allows you to get DNA points when devolving symptoms and the darwinist gene so everytime a new symptom mutated I devolved it immediately.

- I got to step 18 with everyone infected and 89 DNA points after already buying genetic reshuffle I & II so I waited and kept devolving symptoms and collecting DNA until it got to 98.

- Around this time governments randomly find out about the disease but it's considered not dangerous yet.

- Devolve all the transmissions and abilities except genetic reshuffle.

- Buy symptoms to get to total organ failure.

- A cure will immediately begin to be researched. You will have no DNA and people will die too slow.

- Devolve al non-lethal symptoms. When enough people die, you will begin to get additional DNA points.

- Keep evolving the most lethal symptoms you can afford. As soon as you get enough DNA points buy a new symptom.

- Eventually they will stop researching the cure and everyone will die...I my case the cure got to 97%....close call

I hope this helps :)

CanadianGeese on April 18, 2019:

Should i use any genetic codes if so are they specific or do i just disable my genetic codes that i have applied

Cheese on April 11, 2019:

I know im late but is resistance transmission

Ashleign (author) on March 28, 2019:

Eeek.. Glad you won though.

x on March 26, 2019:

barely won, cure was at 98% when the game ended

Ashleign (author) on March 20, 2019:

Dang. Okay, so is there a point where all is swell? It's working great then it all goes to hell? Help me help you.

Me on March 19, 2019:

Sorry. Tried it over ten Times. Doesbt work at all

Ashleign (author) on March 19, 2019:

Hmm.. Sometimes you have to do this tutorial a couple of times. This is one the levels that changes. Try it a third time, and if that doesn't work, we will talk it out.

Kalko on March 18, 2019:

I can't infect Greenland... I tried it 2 times and every time the whole world gets infected and dies except for Greenland. How do i fix this?

Ashleign (author) on March 11, 2019:

Yea, unfortunately, this is one of those you gotta go at it once or twice or six times. I've re-written it a time or two, but it just seems to be a situational one.

JGL on March 09, 2019:

Yeah honestly this doesn't seem to work at all except in the case of infecting everyone. Research just shoots up like a bloody rocket.

deucaliakat on March 07, 2019:

worked perfectly for me, boosted a few "infection" symptoms to infect everyone faster after step 12. needed both reshuffles, but ended the game 831 days cure 56% complete

Tg on March 07, 2019:

This doesn't seem to work very well anymore.

I've tried several times. Everytime I had everyone infected and people dying from organ failure before cure research starts. Despite devolving the unnecessary stuff I never regained enough DNA to do any genetic reshuffling. Cure research even seems to speed up.

Best result was 2 billion dead.

Amazingamer01 on March 05, 2019:

What is air resistance?

James T on March 03, 2019:

Dosent work at all. Tried 4 times even without mutations

V. Fisheri on March 02, 2019:

Following this to a T did not work for me any of the times I’ve tried, I’m going to try again but without allowing persistence of mutations and see if that works.

Slatt316 on February 26, 2019:

Tried this method three times and didn’t work

Nightmare Helpy on February 17, 2019:

I tried this and it worked Thank you

warpaint408 on February 17, 2019:

Comes down to the crunch but works so well! 993 days with 76% cure! Thank you!

a on February 15, 2019:

It was a close call- the cure was 97% complete

Valhalla on February 12, 2019:

So I have an addendum to your guide that worked for me. Instead of allowing mutations, I devolved everything except for coughing and that gave me enough time and extra points to stave off the cure. I finally succeeded after trying that with the cure at 87% complete

Anon on February 12, 2019:

Tried it the updated way....still didn’t even kill half the population of earth before the cure was at 100%

Tim on January 30, 2019:

Update-more depth.. this guide works just beat it.

Once you have reached step 18 and have put all points toward Total Organ Failure you start getting points rapidly because of deaths but however the cure would rapidly increase.

Don’t be alarmed , once you have reach enough DNA points ,put points on genetic reshuffle 1 and wait for points to build up and then finally genetic reshuffle 2. Like the guide said..also in my game after I have gotten genetic resuffle 2 I had build more DNA points for another symptom. Choose what ever you like.

At the end of the game, I followed this guide throughout everyone died but cure was went to a shockling nail biter of 85%. Close call I say.

*important devolve all symptoms that had evolve without costing any DNA points*and then when you reach step 18, put points insomnia till you reach total organ failure*

note: images above... also I would like the give a thank you for this written guide even though most of this comment is repeating what the author has written.

Tim on January 29, 2019:

Guide works, you don’t know the fundamentals of this game.

Stop cheating and play the game normally,

Whenever their is a symptom that had evolved with no DNA points, refund it. So their is cure research.

Reasonable Anonymous on January 07, 2019:

I was about to say this tutorial didn't work, and tried to kill as many people as I could before the cure cured me

Then I remembered evolving symptoms decreses research progress

And I won

Anonymous on January 03, 2019:

It was working really well until people (particularly those in Greenland) just started dying too fast. Somehow those Greenlanders are still going to carry on the world. I'm guessing I should wait until everybody is infected even if I have way more than 100 DNA points.

SilverBluggoe on December 19, 2018:

I have done this many times and it still hasn't worked. The cure is too fast and the deaths are too slow. This tutorial just doesn't work anymore. I'm gonna try one last time though.

iscariott93727 on December 14, 2018:

bro this is a nice tutorial and I appreciate the work you put into it and stuff but it didn’t work for me. I did everything and it was working out pretty well, but then I built my points to 100 that last time (since you said we could either build our points or wait for everyone to be infected) anyways I jumped the gun and started evolving symptoms since the cure was already at 25 percent. turns out Greenland was untouched and I got yeeted upon

Telksy on December 14, 2018:

The written tutorial didnt really work, cure was too quick. Tried some modifications like devolving symptoms until everyone was infected to prevent detection, worked better but still failed. Ultimately the video tutorial worked better and I was able to beat it. I did have to push Neural Atrophy to 3 to stop cure progress though.

The Unknown on December 07, 2018:

Ya know the only tutorials that worked for me is the FREAKIN' BACTERIA AND VIRUS. The others didn't work on me. Like the prion, i have NO DNA when I got Organ failure. It wasn't enough. I'd rate this 4/10 cuz it still helped tho.

(No Offense)

mikeyco on December 06, 2018:

961 days and cure at 70%.

followed tutorial until end where I made slight change.

Once Greenland is infected start making plague more infectious but not lethal. Also slow cure by increasing drug resistance etc...

Once 100% of population is infected started adding lethal symptoms and devolve transmission, heat and cold.

aff on November 28, 2018:

no such thing as dna or not

bs on November 22, 2018:

cure was at 95% when it stopped moving almost lost

Jack Jacoby on November 13, 2018:

You would want to spend your DNA at Genetic Reshuffle no matter what at the end (at least to GR2). There'll be a time when you think, "goddammit I'll not make it on time" but you will.

Deaths will not give you DNA points at first but later it does. I was successful at reaching genetic reshuffle 3 by DEVOLVING ALL OF TRANSMISSIONS and ABILITIES (aside from genetic hardening and genetic reshuffle).

Cuuliu on October 25, 2018:

This time it worked with a few changes.

Researched Genetic Hardening 2 directly after 1.

Waited until everyone was infected - developed symptoms to total organ failure.

Cure research was on my tail so I deleted the tranmissions and resistances to research genetic reshuffle 1. This gave me enough time to gather points for reshuffle 2 and hold the cure back.

Cuuliu on October 25, 2018:

Started developing symptoms as soon as Greenland (last country) was infected.

~100 infected in Greenland and they started executing the sick and beat and no way to reinfect them with closed seaports..

Devildaily on August 30, 2018:

The CURE IS Fast

The Deaths Is SLOW

The DNA Dont Generate

11fastgamer on August 22, 2018:

It works, but dont forget generic reshufel and confuse...

Anonymous on August 17, 2018:

Fifth playthrough using this tutorial, followed everything, keeps getting eradicated.

Obsessed Vampyre on August 09, 2018:

Name: Blood Plague

DNA Sequence: Complex

Difficulty: Casual

Disease Type: Prion

Time: 877 days

Cure Progress: 47% complete

Score Total: 3790 (2/5 Bio Hazards)

Sam Bach on August 05, 2018:

It didnt work

some dude on August 04, 2018:

Now i just have to wait 2 days for it to get to 1000 because of genetic hardening.

felipaoberm on August 02, 2018:

1119 days but I had devolved all transmission and fight the cure (got to 92%) with neural atrophy 1,2 and 3 and genetic reshuffle 2

Willy Cuz on August 02, 2018:

The Neural Atrophy Help stop the cure by making it hard to think. Thats how I stopped it at 80

Garbear on July 22, 2018:

It didn’t work rip off

nobody on July 20, 2018:

I tried this and the cure finished at 200 million people.

ShoKWaiV87 on July 09, 2018:

Does this work on brutal? I'm trying to complete all of them on brutal (I've completed all on normal already) and want to get the cheats (I have premium). Does it work?

Dasupercoolboss on July 03, 2018:

The cure completed at 500 000 000 dead people

snipercat8814 on July 01, 2018:

I had about 30,000 healthy left and the plague killed all of its hosts after I followed all of the instructions I think I should try again and as usual add Total Organ Failure once everyone is infected

ANON on June 08, 2018:

these do take a lot of work and i appreciate your effort. Yet most do not work for me, even as i try them again and again.

The cure either gets developed too quickly or i run out of DNA to actually do anything about it since i spent so much on the contamination options.

CJ on May 06, 2018:

After my second attempt it worked. I used someone else’s tips too and I quickly killed a lot of people

guest on April 27, 2018:

Sorry, this doesn't work anymore even updated

Antonella on April 23, 2018:

Yes, I'm the same person that wrote yesterday. I followed your instructions again and again and, after 4 times I finally made it. Everyone was dead and research stopped at 90%.

I guess that the game's IA may be more complex and also adapt to what the player does.

I've followed all your walkthroughs to the T and some may take a few times to work but they do. Also I'd like to thank you for all your hard work.

Going to nano now! Bye!

Antonella on April 22, 2018:

I followed your instructions and when the cure was complete Greenland was still 100% healthy.

N/A on April 12, 2018:

This doesn’t work

N/A on March 24, 2018:

Don't get genetic hardening.

n/a on March 13, 2018:

Worked great! Won at 78%. Thanks for the help!

nope on March 02, 2018:

followed these instructions perfectly and the cure beat me. it went down when i added more symptoms but by then the disease was killing people faster than it infected them. also the mutated symptoms alerted people who closed borders which generally made it harder, and iceland had a low infection rate so they executed the infected and closed their borders which meant i couldn't win. it is not due to people not following these steps, it is down to many variables that cannot be foreseen in individual gameplay. this tutorial will work for some and not for others, unfortunately i was not one of the lucky ones.

Duey on February 21, 2018:

Thanks for your hard work. I must be missing something. I can't seem to win. The cure is always reached so quickly once I get to total organ failure. People just aren't dying very fast. I'll give it another go

N/A on February 19, 2018:

The cure got to 98%. Just barely won.

Mackenzy on February 04, 2018:

For people saying it didn't work and that you followed it to a T obviously you didn't. She has worked hard on these tutorials and doesn't deserve the bullshit i see in the comments. If you followed her steps to the letter, then it should work. I have used her tutorials for the past hour and have gotten all the way up to this disease with her help and i kept dying for days stuck at the Bacteria level. So obviously you didn't follow instructions therefore it isnt her fault

Fabian on January 06, 2018:

Doesn’t work I’ve done it 6 times and I always get eradicated before they all die.

Ganegirl on January 02, 2018:

Doesnt work for me.. i tried it two times still canmt beat it

William on December 04, 2017:

for those who lose, I beat it at 99% left to cure it, after you use Genetic reshuffles, make sure to devolve transmissions and abilities and put towards symptoms like Coma and Insanity (To the left) that slows down progress, then just pray that the leading nation of the cure dies out. Hope this helps

Michael on November 27, 2017:

You tutorials work like like.... idk but they’d work

All of them thank you!

Marcus on November 24, 2017:

this worked thank you

Joe on November 05, 2017:

I followed to a T and was defeated twice at the last minute. The most DNA points I can get after step 16 is 71 and then it outright stops. Devolved all symptoms and abilities to fight the cure, which takes less than a minute to reach 100%. Ive lost to this level a total of 9 times now. :(

Geoff on October 31, 2017:

On the normal prion I found that I had to devolve symptoms to escape detection. I reached 98% world infection before new disease was receiving attention. Once I got 100% your advice of ramping up symptoms to kill and genetic reshuffling worked like a charm.

Gravy on October 08, 2017:

Barely worked, however did in the end! I had to take some extra action to defend against the cure though, like devolving certain transmissions and abilities, and evolving the Prion's special ability at the beginning, along with adding extra lethal symptoms, but it worked!