The Ten Best Items in "The Binding of Isaac: Rebirth"

Updated on May 28, 2020
EricFarmer8x profile image

Eric loves to play "The Binding of Isaac: Rebirth" on Steam, and it is one of his favorite games. He wants to teach others about the game.

The Good Stuff

In this list, I am going to go over what I think the best items in The Binding of Isaac: Rebirth. These are the items that often change a game session from bad to good or from OK to amazing.

I play the game with all expansions installed. Also, I am sure a few people will disagree with my choices, and that is OK.

Also, these items are not exactly in order. For one choosing an order would be very hard. So everything is in alphabetical order.

20/20 | Source


You find 20/20 in Treasure Rooms.

When I think of good items in The Binding of Isaac: Rebirth, 20/20 is one of the best. This item allows you to shoot two tears at the same time.

There are no downsides to this item. If you aim well, you have double damage. Also, unlike the Mutant Spider or The Inner Eye items, 20/20 does not make your tears stat worse.

Brimstone | Source


You find Brimstone in Devil Rooms. The item always costs two red heart containers.

This item gives you a slowly charged beam that hits everything in its path. This beam does more damage than you might think because a full-beam hits enemies about 13 times.

This is a great item, and while you have to learn to shoot differently with it, that is the only downside. If I have the health, I will almost always grab this item.

Capricorn | Source


This item increases most of your stats. It also increases your tear delay. This allows you to get to four tears instead of the normal five.

Items that make you better overall are always good. This item also allows you to potentially have better tears end game.

Cricket's Head
Cricket's Head | Source

Cricket's Head

You find Cricket's Head in Golden Chests and Treasure Rooms.

Crickets Head is a great item for the bonus damage it gives. The item multiplies your damage by 1.5.

This is amazing, and this helps no matter how much damage you have. The item gives you a tiny damage increase as well.

There is nothing bad about this item at all. I wish I found it a bit more.

Magic Mushroom
Magic Mushroom | Source

Magic Mushroom

You find Magic Mushroom in Treasure Rooms and the Boss item pool.

Magic Mushroom is a great item that makes your stats better overall. It increases most of your stats. It feels like an alternative version of Cricket’s Head.

But that alone is not what makes this item great. What makes this a good item is the damage multiplier you get. The item multiplies your damage by 1.5.

But the damage multiplier does not stack with Cricket’s Head and some other items. That would be too good, I suppose.

The only annoying thing about this item is the size increase.

Sacred Heart
Sacred Heart | Source

Sacred Heart

You find Sacred Heart in Angel Rooms.

Sacred Heart is one of the best items in the game. You do not have to unlock the item either.

The item has a flat increase in damage by one. But what makes this item good is the 2.3 damage multiplier. This is the best damage multiplier you can find in the game!

The damage multiplier alone would make this one of the best items in the game. But this item has even more!

Sacred Heart fully heals your health and gives you one red heart container. It also gives you homing tears, and this item even gives your bombs a homing effect.

The item also makes your shots slower, and this lowers your overall shot range. But this is nothing compared to the good the item does.

This item makes me consider trying to get into Angel Rooms instead of Devil Rooms.

Sinus Infection
Sinus Infection | Source

Sinus Infection

You find Sinus Infection in Treasure Rooms.

While multiple items give poison damage, I like Sinus Infection the most. This item does more damage to bosses. This item makes even the hardest boss fights much easier.

The hardest bosses in the game have a special armor that stops you from doing a lot of damage to them at once. But items like this bypass the armor by attacking them many times at once for a tiny amount of damage.

The only downside is the enemies jump the boogers will fall off.

SMB Super Fan
SMB Super Fan | Source

SMB Super Fan

You find SMB Super Fan in Treasure Rooms.

SMB Super Fan increases most of your stats a tiny bit, and you gain a full red heart container.

I love items like this. Most items that increase your overall stats increases are very helpful.

Tech X
Tech X | Source

Tech X

You find Tech X in Treasure Rooms.

Tech X turns your tears into giant rings. If you hold down your shooting input, you will shoot bigger rings. These rings travel the length of the whole room, and this item gives you unlimited range.

With this item, you can keep your distance and shoot giant rings at enemies far away. This allows for a much safer game.

Also, since the outer part of the rings does damage, you can hit enemies multiple times with one ring.

The Halo
The Halo | Source

The Halo

You find The Halo in Treasure Rooms, Angel Rooms, and the Boss item pool.

The Halo gives most of your stats a small increase and gives you a full red heart container.

If some of your stats have low points, this item helps by increasing everything. I love finding this item when playing as Eden.

Other Good Items

  • Abaddon: Gives you damage and replaces your red hearts with black.
  • Chocolate Milk: You now have charged shots that do more damage.
  • Godhead: Good item that gives homing tears and a damage aura.
  • Holy Light: The effect does good damage.
  • Lump of Coal: Your tears do more damage based on distance with this item.
  • Mom’s Knife: This item is risky, but it does very high damage.
    Mutant Spider/The Inner Eye: Good items, but the slower tears are somewhat annoying.
  • Polyphemus: You now have high damage tears that shoot slowly.
  • Serpent's Kiss: an item that gives your tears poison and has a chance to gain extra black hearts.
  • Technology Zero/Jacob's Ladder: The damage from the electricity jumps helps a lot in clearing rooms

© 2020 Eric Farmer


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