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The Ten Worst Items in “The Binding of Isaac: Rebirth”

Eric loves to play "The Binding of Isaac: Rebirth" on Steam, and it is one of his favorite games. He wants to teach others about the game.


The Binding of Isaac: Rebirth Items to Avoid

I am going to list the worst items in The Binding of Isaac: Rebirth. I will explain why these items are bad and so frustrating. These items tend to do more harm than good.

These items are good in certain situations. But it takes luck to get the right combination for these items to be great.

In a game like The Binding of Isaac: Rebirth, you want items that are always good or at least neutral. Items that are sometimes bad are the stuff I mostly just ignore.

A lot of the weirder and bad items are found in the Treasure Room item pool. This item pool has the most items.

List Information

I play the game will all expansions installed. This list assumes that you do as well. I have updated the guide for Repentance.

Also, you might disagree with an item that you think is good or not so bad. That is fine as everybody has their opinions after all.

Repentance List Changes

Glass Cannon

Glass Cannon is now interesting. Previously Glass Cannon was insanely risky. Now it is much more balanced. Now when you take damage, the item breaks. You need to recharge it to fix it. While broken, you receive double damage. But if the attack would kill you, you will be left at half a red heart. The item seems a bit much safer now, and I will need to experiment using it. But either way, the item is no longer one of the worst items in the game.

Holy Water

This has been one of the most interesting Repentance changes. Previously Holy Water was disappointing. Holy Water now is a thrown familiar like Bob's Brain. It also petrifies enemies who touch the creep pool. I would even consider this item to be one of the better items in the game now. What a turnaround!


Now that you can turn Marked off I feel warmer to the possibility of the item being OK. The odd aiming stills feel weird but I don't see the item as bad anymore.

No. 2

No. 2

No. 2

You find No. 2 in Treasure Rooms. When you have No. 2, firing tears for three seconds drops a Butt Bomb. These bombs deal ten damage to all enemies in the room. You only drop one bomb while holding down fire at a time.

The bombs are helpful early game. They help you get into secret rooms and find more items. Bomb damage is great against some early game bosses. But the bombs become a nuisance over time. Any item that forces me to dodge another obstacle is rarely worth the hassle long term. There is enough in this game to worry about. I don’t want to remember to dodge a bomb after firing for three seconds as well.

Having Pyromaniac turns No. 2 into an amazing item, though!

Bob's Brain

Bob's Brain

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Bob's Brain

You find Bob's Brain in Treasure Rooms and Golden Chests. You can also get Bob's Brain from Rotten Beggars.

Bob’s Brain is a floating bomb. The bomb flies forward after a delay. This triggers when you fire tears. The brain explodes with whatever enemy it makes contact with. After so long, it will come back.

The item is the most useful early game. Early game the extra damage is a great help. Bob’s Brain destroys some of the early game bosses. But often during the late game, you no longer need the extra damage. At this point, this item becomes a liability. If the explosion happens too close, you also get damaged. This is why most people dislike the item. If you are not careful, you can die from using this item.

This item would be perfect if I could drop it when I no longer needed it. The only way to get rid of items is to reroll every item you have, and this is very risky to do.

Cursed Eye

Cursed Eye

Cursed Eye

You find Cursed Eye in Red Chests, Secret Rooms, and Treasure rooms. Cursed Eye allows you to shoot out tears in charged shots. If you take damage while charging shots, the item teleports you to a random room. Being teleported like this is very jarring. Also, when teleported out of boss fights, you have to restart the fight from the beginning.

This item can be good under the right circumstances. The Black Candle item removes all curses. Even Cursed Eye. Without the curse, Cursed Eye becomes Charged Shot Eye? It is a great item without the curse.

Also, if you have very high tears, you will shoot so fast that the chance of getting hit while charging shots is low. You will be able to manage this risk more.

Curse of the Tower

Curse of the Tower

Curse of the Tower

You find Curse of the Tower in Red Chests, Curse Rooms, and Treasure Rooms. Curse of the Tower spawns six troll bombs when you take damage. These bombs can hurt you as well as enemies. This item can be useful in some situations. Often the bombs will help you clear a room after getting hit. But the bombs are also risky. I don’t want items with risks that change how I need to play the game. There is enough in this game to worry about than needing to dodge six bombs every time I get damaged. Often I take damage again from the bombs.

Some items make Curse of the Tower great or better. If you happen to have Pyromaniac, then Curse of the Tower is a great item in this situation. The bombs now heal you if you have red heart containers.

The trinket Safety Scissors will turn the troll bombs into free bomb pickups you can grab. Defensive-based items somewhat mitigate the damage. Holy Mantle is a good item that helps here.

If you have a lot of health or a way to get health back fast, you don't have to worry too much about the bomb damage.




You find Ipecac in Treasure Rooms. Ipecac turns your tears into slow high damage explosive shots. This does a lot of damage to single enemies. These shots can hurt you too if the explosion happens to close to you. Ipecac is very risky to use. You have to be very careful not to hurt yourself in the process. Even with the best intentions, I will often end taking some damage. You have to act as each shot is a threat to your safety.

Shooting too fast or having tears with a short-range is dangerous. Any item that splits your tears is also dangerous as it causes you to take damage more often. The item my reflection is suicide as if you miss the tears will fly back at you. The Suicide King challenge was such a pain to complete because of this. This is why I dislike the item, and I will refuse to pick it up sometimes. I don’t feel the risk justifies the high damage.

Some items make Ipecac worth picking up. Pyromaniac turns any explosive items into absolute wins. Items that create flies or spiders become epic items. Remember, the game calculates spider and fly damage based on your damage. So having high damage gives them great damage With high damage blue spiders demolishes bosses with a single touch. It is very funny to see a boss die from touching a tiny blue spider.

Defensive items like the Holy Mantle somewhat help with dodging the self-inflicted damage.

Kidney Stone

Kidney Stone

Kidney Stone

You find Kidney Stone in Treasure Rooms. The item lowers your tear distance. Every so often will spit out a kidney stone, and this shoots out a barrage that is somewhat hard to aim. This item is more annoying than good. The lowered range is a huge nuisance. Also, you spit out stones somewhat randomly. This is annoying to deal with as now I have to pay attention to when the charged shots happen. I suppose this item would result in more damage overall, but I don’t think it is worth it.

Shard of Glass

Shard of Glass is only found in Treasure rooms. It adds a 25% chance to drop a red heart. After taking damage, you will bleed and shoot out red tears constantly. If you bleed for too long, you will take damage. This damage only ends when you pick up a red heart container. Or if the next hit would kill you and end the run. This item was previously forgettable. But now it is quite bad.

I don't see why you would want this item. You start to bleed, and unless you can get red hearts, you will eventually lose all of your health. I don't see the risk as being worth what you get. All you get is a tiny stream of red tears that you can aim at things. If you have high health, maybe the item could work? I don't think so, though. I rather not have the item at all.

Soy Milk

Soy Milk

Soy Milk

You find Soy Milk in Treasure Rooms. Soy Milk makes your tears stat as low as possible. It also greatly lowers your damage and future damage upgrades. You shoot out very fast, weak tears. This item is a bit more controversial than bad. It just feels odd and weird to shoot tiny tears for low damage. If you land every shot you are actually doing about the same damage but it just doesn't seem like it. This item has a chance to be good. With the right passive items, you can do more damage than the tiny damage stat shows.

You need items like Apple!, Tough Love, Chemical Peel, Blot Clot, Holy Light, etc. But in most cases, you will do tiny damage. Soy Milk will make you seem weaker than you are. Also, the item is worse to pick up if you already have good tears. I might risk picking up Soy Milk early game. But often, late in the game I refuse to pick up the item if I like my damage.

Tiny Planet

Tiny Planet is found in Treasure Rooms. Tiny Planet gives tear height and makes tears spectral. Tears now pass through all obstacles. Your tears now float around you like satellites orbiting a planet. Spectral tears are neat. But overall, I don't like this item. I just can't get used to tears floating around you. I suppose with enough tears and range Tiny Planet might be a good item. But I rather not have to make such huge adjustments to how I aim tears. I rather keep things simple.

The Wiz

The Wiz is found in Treasure rooms. The Wiz makes to start to shoot tears diagonally just like while under the effects of a R U a Wizard pill. Your tears travel over everything. I have no idea why you would want this item. It makes it so you can't ever hit anything with both tears again. This item works well with Tractor Beam, I guess. But I don't like either item, and I doubt the odds are good at getting both.

© 2020 Eric Farmer

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